Psychotic experiences in seven-year-old children with familial high risk of schizophrenia or bipolar disorder in: The Danish High Risk and Resilience Study - VIA 7; A population-based cohort study.

Détails

ID Serval
serval:BIB_E81392A6C861
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Psychotic experiences in seven-year-old children with familial high risk of schizophrenia or bipolar disorder in: The Danish High Risk and Resilience Study - VIA 7; A population-based cohort study.
Périodique
Schizophrenia research
Auteur(s)
Ellersgaard D., Gregersen M., Spang K.S., Christiani C., Burton B.K., Hemager N., Søndergaard A., Greve A., Gantriis D., Jepsen JRM, Mors O., Plessen K.J., Thorup AAE, Nordentoft M.
ISSN
1573-2509 (Electronic)
ISSN-L
0920-9964
Statut éditorial
Publié
Date de publication
02/2021
Peer-reviewed
Oui
Volume
228
Pages
510-518
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
We aimed to examine the prevalence of psychotic experiences (PEs) in children with familial high risk of schizophrenia (FHR-SZ) or bipolar disorder (FHR-BP) and, in exploratory analyses, to examine the possible associations between PEs and mental disorders as well as level of functioning. A cohort of seven-year-old children with FHR-SZ (N = 199), FHR-BP (N = 118) and controls (N = 196) was recruited through Danish nationwide registers. Lifetime PEs were assessed through interviews using the psychosis section of the 'Schedule for Affective Disorders and Schizophrenia for School-Age Children - Present and Lifetime Version' (K-SADS-PL). Lifetime DSM-IV diagnoses were ascertained through K-SADS-PL and the level of functioning of the children through 'Children's Global Assessment Scale'. Both children with FHR-SZ (OR = 2.9, 95% CI = 1.4-6.2, p = 0.005) and FHR-BP (OR = 2.9, 95% CI = 1.3-6.7, p = 0.011) had an increased risk of having experienced "severe" PEs compared with controls. In the overall cohort PEs were associated with any lifetime mental disorder, Attention-Deficit/Hyperactivity Disorder, anxiety disorders and a lower level of functioning. The findings of a higher proportion of high risk children reporting PEs could represent an early manifestation of later more severe psychopathology or simply an unspecific transitory symptom. Future follow-up studies of this cohort will explore the predictive value of the occurrence of PEs at age seven.
Mots-clé
Bipolar disorder, Developmental psychopathology, Familial high risk, Offspring, Psychotic experiences, Schizophrenia
Pubmed
Web of science
Création de la notice
22/12/2020 10:41
Dernière modification de la notice
17/04/2021 5:33
Données d'usage