A family of human CCAAT-box-binding proteins active in transcription and DNA replication: cloning and expression of multiple cDNAs.
Détails
ID Serval
serval:BIB_E8124AD8E29E
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
A family of human CCAAT-box-binding proteins active in transcription and DNA replication: cloning and expression of multiple cDNAs.
Périodique
Nature
ISSN
0028-0836[print], 0028-0836[linking]
Statut éditorial
Publié
Date de publication
07/1988
Volume
334
Numéro
6179
Pages
218-224
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S.
Publication Status: ppublish
Publication Status: ppublish
Résumé
The CTF/NF-I group of cellular DNA binding proteins recognizes the sequence GCCAAT and is implicated in eukaryotic transcription as well as DNA replication. Molecular analysis of human CTF/NF-I complementary DNA clones reveals multiple messenger RNA species containing alternative coding regions, apparently as a result of differential splicing. Expression and functional analysis establish that individual gene products can bind to GCCAAT recognition sites and serve both as promoter-selective transcriptional activators and as initiation factors for DNA replication.
Mots-clé
Adenoviridae/genetics, Amino Acid Sequence, Base Sequence, Cloning, Molecular, DNA/genetics, DNA Replication, DNA-Binding Proteins/genetics, Humans, Molecular Sequence Data, Promoter Regions, Genetic, RNA Polymerase II/metabolism, RNA Splicing, Transcription Factors/genetics, Transcription, Genetic, Virus Replication
Pubmed
Web of science
Création de la notice
24/01/2008 11:41
Dernière modification de la notice
20/08/2019 17:10
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