TRAF2 deficiency results in hyperactivity of certain TNFR1 signals and impairment of CD40-mediated responses
Détails
ID Serval
serval:BIB_E808895C55DE
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
TRAF2 deficiency results in hyperactivity of certain TNFR1 signals and impairment of CD40-mediated responses
Périodique
Immunity
ISSN
1074-7613 (Print)
Statut éditorial
Publié
Date de publication
09/1999
Volume
11
Numéro
3
Pages
379-89
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Sep
Research Support, Non-U.S. Gov't --- Old month value: Sep
Résumé
Tumor necrosis factor (TNF) receptor-associated factor 2 (TRAF2) can interact with various members of the TNF receptor family. Previously, we reported that TRAF2-deficient mice die prematurely and have elevated serum TNF levels. In this study, we demonstrate that TRAF2-deficient macrophages produce increased amounts of nitric oxide (NO) and TNF in response to TNF stimulation. Furthermore, we could enhance the survival of TRAF2-deficient mice by eliminating either TNF or TNFR1. Using these double-knockout mice, we show that in the absence of TRAF2, the T helper-dependent antibody response, CD40-mediated proliferation, and NF-kappaB activation are defective. These data demonstrate two important roles of TRAF2, one as a negative regulator of certain TNFR1 signals and the other as a positive mediator of CD40 signaling.
Mots-clé
Animals
Antigens, CD/*metabolism
Antigens, CD40/*metabolism
Cell Division
Cells, Cultured
Female
Immunoglobulin Class Switching
Immunoglobulin Isotypes
Interleukin-12/biosynthesis
Macrophages, Peritoneal/cytology/metabolism
Male
Mice
Mice, Inbred BALB C
Mice, Inbred C57BL
Mice, Knockout
NF-kappa B/metabolism
Nitric Oxide/biosynthesis
Nitric Oxide Synthase/genetics
Nitric Oxide Synthase Type II
Phenotype
Proteins/genetics/*physiology
Receptors, Tumor Necrosis Factor/*metabolism
Receptors, Tumor Necrosis Factor, Type I
*Signal Transduction
Spleen/cytology
TNF Receptor-Associated Factor 2
Tumor Necrosis Factor-alpha/biosynthesis
Vesicular stomatitis-Indiana virus
Pubmed
Web of science
Open Access
Oui
Création de la notice
28/01/2008 12:32
Dernière modification de la notice
20/08/2019 17:10