Absence of nocturnal acid breakthrough in Helicobacter pylori-positive subjects treated with twice-daily omeprazole

Détails

ID Serval
serval:BIB_E7E9683A68B8
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Absence of nocturnal acid breakthrough in Helicobacter pylori-positive subjects treated with twice-daily omeprazole
Périodique
European Journal of Gastroenterology and Hepatology
Auteur⸱e⸱s
Martinek  J., Pantoflickova  D., Hucl  T., Benes  M., Dorta  G., Lukas  M., Spicak  J.
ISSN
0954-691X (Print)
Statut éditorial
Publié
Date de publication
05/2004
Volume
16
Numéro
5
Pages
445-50
Notes
Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't --- Old month value: May
Résumé
BACKGROUND: Proton pump inhibitors (PPIs) taken twice daily do not effectively control night-time intragastric pH; nocturnal acid breakthrough (NAB) (arbitrarily defined as intragastric pH < 4 lasting longer than 1 h) occurs in more than 75% of patients. The effectiveness of PPIs depends rather on the Helicobacter pylori status. OBJECTIVES: To investigate the effectiveness of two regimens of omeprazole in H. pylori-positive subjects as well as the occurrence of NAB. PATIENTS: Fifteen otherwise healthy H. pylori-positive subjects participated in this randomized, crossover, double-blind study. METHODS: Night-time intragastric pH-metry was performed before (baseline) and on day 7 of two treatment courses with omeprazole (1 x 20 mg and 2 x 20 mg). A 14-day (minimum) wash-out period was respected between the two treatment courses. RESULTS: Group medians (10-90% confidence intervals) for night-time intragastric pH (22:30-06:30 h) were as follows: baseline, 2 (1-6.1); 1 x 20 mg, 5 (3.3-6.9; P < 0.001 versus baseline); instead of, 2 x 20 mg, 6.3 (4.9-7.1; P < 0.001 versus baseline, P = 0.02 versus omeprazole 1 x 20 mg). The percentage of time with intragastric pH < 3 was 65.4% during baseline (P < 0.05 versus both omeprazole regimens), 27% with once-daily omeprazole (P = 0.001 versus omeprazole 2 x 20 mg) and 0% with twice-daily omeprazole. NAB occurred in eight (53.3%) subjects with once-daily omeprazole and in no subject taking twice-daily omeprazole. CONCLUSIONS: In H. pylori-positive subjects, twice-daily omeprazole is highly effective in controlling nocturnal intragastric acidity. NAB does not occur in those subjects and there is no need to add bedtime H2-receptor antagonists to this regimen.
Mots-clé
Adult Breath Tests Cross-Over Studies Double-Blind Method Drug Administration Schedule Female Gastric Acid/*secretion Gastric Acidity Determination Helicobacter Infections/*complications/diagnosis/metabolism *Helicobacter pylori Humans Hydrogen-Ion Concentration Male Omeprazole/*administration & dosage/therapeutic use Prospective Studies Proton Pumps/*antagonists & inhibitors Statistics, Nonparametric
Pubmed
Web of science
Création de la notice
25/01/2008 15:48
Dernière modification de la notice
20/08/2019 16:10
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