Maternal hormones during early pregnancy: a cross-sectional study.

Détails

Ressource 1Télécharger: BIB_E7E16FC4EBCE.P001.pdf (772.24 [Ko])
Etat: Public
Version: Author's accepted manuscript
ID Serval
serval:BIB_E7E16FC4EBCE
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Maternal hormones during early pregnancy: a cross-sectional study.
Périodique
Cancer Causes and Control : Ccc
Auteur(s)
Chen T., Lundin E., Grankvist K., Zeleniuch-Jacquotte A., Wulff M., Afanasyeva Y., Schock H., Johansson R., Lenner P., Hallmans G., Wadell G., Toniolo P., Lukanova A.
ISSN
1573-7225 (Electronic)
ISSN-L
0957-5243
Statut éditorial
Publié
Date de publication
2010
Peer-reviewed
Oui
Volume
21
Numéro
5
Pages
719-727
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural
Publication Status: ppublish
Résumé
BACKGROUND: Little is known about correlates of first-trimester pregnancy hormones as in most studies maternal hormones have been measured later in gestation. We examined the associations of maternal characteristics and child sex with first-trimester maternal concentrations of four hormones implicated in breast cancer: human chorionic gonadotropin (hCG), alpha-fetoprotein (AFP), insulin-like growth factor (IGF)-I, and IGF-II.
METHODS: About 338 serum samples donated to the Northern Sweden Maternity Cohort (NSMC), 1975-2001, during the first trimester of uncomplicated pregnancies, were analyzed for the hormones of interest as a part of a case-control study. The associations of maternal characteristics and child sex with hormone concentrations were investigated by correlation, general linear regression, and multivariate regression models.
RESULTS: In the first trimester, greater maternal age was inversely correlated with IGF-I and IGF-II. In comparison with women carrying their first child, already parous women had higher IGF-I but lower hCG. Greater maternal weight and smoking were inversely correlated with hCG. No differences in hormone levels by child sex were observed.
CONCLUSIONS: Our analyses indicated that potentially modifiable maternal characteristics (maternal weight and smoking) influence first-trimester pregnancy maternal hormone concentrations.
Mots-clé
Adult, Body Weight, Chorionic Gonadotropin/blood, Cross-Sectional Studies, Female, Humans, Insulin-Like Growth Factor I/metabolism, Insulin-Like Growth Factor II/metabolism, Maternal Age, Parity, Pregnancy, Pregnancy Trimester, First/blood, alpha-Fetoproteins/metabolism
Pubmed
Web of science
Création de la notice
26/10/2016 15:32
Dernière modification de la notice
20/08/2019 16:10
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