Olive oil phenols modulate the expression of metalloproteinase 9 in THP-1 cells by acting on nuclear factor-kappaB signaling.

Détails

ID Serval
serval:BIB_E7AC50FBD1BB
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Olive oil phenols modulate the expression of metalloproteinase 9 in THP-1 cells by acting on nuclear factor-kappaB signaling.
Périodique
Journal of agricultural and food chemistry
Auteur(s)
Dell'Agli M., Fagnani R., Galli G.V., Maschi O., Gilardi F., Bellosta S., Crestani M., Bosisio E., De Fabiani E., Caruso D.
ISSN
1520-5118 (Electronic)
ISSN-L
0021-8561
Statut éditorial
Publié
Date de publication
24/02/2010
Peer-reviewed
Oui
Volume
58
Numéro
4
Pages
2246-2252
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
In vivo studies suggest that the phenolic component contributes to the anti-inflammatory and antiatherosclerotic actions of olive oil; however, the effects in circulating cells are not fully characterized. Monocytes play a key role in inflammation-based diseases by expressing several molecules, including metalloproteinases (MMPs). In the present study, we investigated the effects of olive oil phenolic extract and individual compounds on MMP-9 in THP-1 cells, a human monocyte-like cell line. Olive oil extract prevented the stimulation of MMP-9 expression and secretion in tumor necrosis factor alpha-treated THP-1 cells. Oleuropein aglycone, a typical olive oil phenol, was active at concentrations found in the extract, although other compounds probably contribute to the biological activity. We also found that the effect of the extract and individual compounds on MMP-9 is due to impaired nuclear factor-kappaB signaling. Our findings provide further evidence on the mechanisms by which olive oil reduces the inflammatory burden associated with disorders, such as atherosclerosis.
Mots-clé
Cell Line, Tumor, DNA Primers, Gene Expression Regulation, Enzymologic/drug effects, Gene Expression Regulation, Neoplastic/drug effects, Humans, Leukemia, Myeloid, Matrix Metalloproteinase 9/genetics, NF-kappa B/genetics, NF-kappa B/physiology, Olive Oil, Phenols/isolation & purification, Phenols/pharmacology, Plant Oils/chemistry, Promoter Regions, Genetic, Reverse Transcriptase Polymerase Chain Reaction, Signal Transduction/drug effects, Signal Transduction/physiology, Transcription, Genetic/drug effects, Tumor Necrosis Factor-alpha/pharmacology
Pubmed
Web of science
Création de la notice
21/03/2019 11:29
Dernière modification de la notice
20/02/2020 6:26
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