Effect of deep brain stimulation of GPI on neuronal activity of the thalamic nucleus ventralis oralis in a dystonic patient

Détails

ID Serval
serval:BIB_E7AB38C839A9
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Etude de cas (case report): rapporte une observation et la commente brièvement.
Collection
Publications
Institution
Titre
Effect of deep brain stimulation of GPI on neuronal activity of the thalamic nucleus ventralis oralis in a dystonic patient
Périodique
Neurophysiologie Clinique
Auteur(s)
Pralong E., Debatisse D., Maeder M., Vingerhoets F., Ghika J., Villemure J. G.
ISSN
0987-7053 (Print)
Statut éditorial
Publié
Date de publication
09/2003
Volume
33
Numéro
4
Pages
169-73
Langue
anglais
Notes
Case Reports
Journal Article --- Old month value: Sep
Résumé
OBJECTIVE: To record the possible effect of acute deep brain stimulation (DBS) of the globus pallidus internus (GPI) on the neuronal activity of the ventralis oralis anterior (VOA) nucleus of the thalamus. METHODS: Under general propofol anaesthesia, extracelullar single unit recordings were performed in VOA of a post-anoxic dystonic patient previously implanted with GPI located electrodes for chronic DBS. RESULTS: Neurons recorded in the VOA could be classified in two cell subpopulations: a high firing rate (16.5 Hz) and low burst index (BI; 15.6) type and a low firing rate (5.5 Hz) and high BI (35.6) type. GPI electrical stimulation reduced the frequency and increased the BI of the high firing rate cells while leaving the other cell type unchanged. CONCLUSION: These results demonstrate that pallidal DBS is able to inhibit a subpopulation of motor thalamic cells and question the pathophysiological model of dystonia based on a low firing rate of GPI cells.
Mots-clé
Adult Anesthesia, Intravenous Anesthetics, Intravenous Dystonia/*physiopathology/therapy Electric Stimulation Electrodes, Implanted Electrophysiology Extracellular Space/physiology Globus Pallidus/*physiology Humans Magnetic Resonance Imaging Male Neurons/*physiology Propofol Stereotaxic Techniques Suicide Ventral Thalamic Nuclei/*cytology/*physiology
Pubmed
Web of science
Création de la notice
25/01/2008 12:49
Dernière modification de la notice
20/08/2019 16:10
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