Histiocytic and dendritic cell neoplasms: what have we learnt by studying 67 cases.

Détails

ID Serval
serval:BIB_E77E39634693
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Histiocytic and dendritic cell neoplasms: what have we learnt by studying 67 cases.
Périodique
Virchows Archiv
Auteur(s)
Facchetti F., Pileri S.A., Lorenzi L., Tabanelli V., Rimsza L., Pittaluga S., Dirnhofer S., Copie-Bergman C., de Leval L., Rosenwald A., Wotherspoon A., Fend F.
ISSN
1432-2307 (Electronic)
ISSN-L
0945-6317
Statut éditorial
Publié
Date de publication
10/07/2017
Peer-reviewed
Oui
Volume
471
Numéro
4
Pages
467-489
Langue
anglais
Notes
Publication types: Journal Article

Résumé
Tumors derived from histiocytic and dendritic cells encompass a large and heterogeneous group of neoplastic and reactive conditions, and their diagnosis is challenging both for pathologists and clinicians. Diagnosis is based on morphological and phenotypical findings, but hybrid features are not uncommon. Furthermore, recent studies uncovered the molecular mechanisms driving some of these tumors, improving diagnostic adequacy, and providing the basis for effective therapeutic breakthroughs.Sixty-seven cases were submitted to the accessory cell and histiocytic neoplasms session at the European Association of Haematopathology/Society for Hematopathology workshop 2016 held in Basel, Switzerland. The cases included histiocytic sarcomas (HS), Langerhans cell tumors (LCT), Erdheim-Chester disease, interdigitating dendritic cell sarcomas (IDCS), indeterminate dendritic cell tumors (IND-DCT), follicular dendritic cell sarcomas, and blastic plasmacytoid dendritic cell neoplasms. Rosai-Dorfman disease and, more rare, conditions such as ALK-positive histiocytosis were also submitted. These cases illustrated classical and unexpected features at morphological, phenotypical, and molecular levels, providing a valuable compendium for pathologists confronting with these tumors.The paper summarizes the most notable features of every single group of diseases, with comments about the most challenging issues, in the attempt to provide practical indications for their recognition.

Mots-clé
Dendritic cells, Histiocytes, Neoplasms, Tumors
Pubmed
Web of science
Création de la notice
12/07/2017 12:21
Dernière modification de la notice
20/08/2019 16:10
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