Magnetic resonance imaging and proton spectroscopic alterations correlate with parkinsonian signs in patients with cirrhosis.

Détails

ID Serval
serval:BIB_E767060E1C93
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Magnetic resonance imaging and proton spectroscopic alterations correlate with parkinsonian signs in patients with cirrhosis.
Périodique
Gastroenterology
Auteur(s)
Spahr L., Vingerhoets F., Lazeyras F., Delavelle J., DuPasquier R., Giostra E., Mentha G., Terrier F., Hadengue A.
ISSN
0016-5085[print], 0016-5085[linking]
Statut éditorial
Publié
Date de publication
2000
Peer-reviewed
Oui
Volume
119
Numéro
3
Pages
774-781
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
BACKGROUND & AIMS: The relationship between abnormalities found by magnetic resonance imaging (MRI) and proton spectroscopy (MRS) and the clinical signs of hepatic encephalopathy is not well characterized. Motor disturbances have been described, suggesting that basal ganglia (BG) are altered. METHODS: We evaluated 19 unselected consecutive patients with biopsy-proven cirrhosis evaluated for liver transplantation for the presence of parkinsonian signs using the Unified Parkinson's Disease Rating Scale (UPDRS) and Purdue Pegboard test, and correlated these neurologic abnormalities with MRI and MRS studies. Brain MRI intensities were expressed as signal-to-noise ratios. MRS findings obtained from one voxel in the BG and one in the occipital white matter (WM) were expressed as metabolite ratios. Six healthy subjects had normal values. RESULTS: Compared with healthy subjects, patients with subclinical or grade 1 hepatic encephalopathy had hyperintensity in occipital WM and all BG tissues except thalamus and reduced Ino/Cr and Cho/Cr ratios in both voxels. In the BG, MRI intensity was correlated with the UPDRS (P < 0.05, r = 0.56). The Cho/Cr ratio also correlated with both UPDRS (P < 0.02, r = -0.59) and Pegboard scores (P < 0.02, r = 0.61). CONCLUSIONS: In cirrhosis, parkinsonian signs correlate with BG alterations detected by MRI and MRS.
Mots-clé
Adult, Brain/pathology, Female, Hepatic Encephalopathy/diagnosis, Hepatic Encephalopathy/physiopathology, Humans, Liver Cirrhosis/diagnosis, Liver Cirrhosis/physiopathology, Liver Transplantation, Magnetic Resonance Imaging, Magnetic Resonance Spectroscopy/diagnostic use, Male, Middle Aged, Neurologic Examination, Parkinsonian Disorders/physiopathology, Parkinsonian Disorders/psychology, Prospective Studies, Psychiatric Status Rating Scales
Pubmed
Web of science
Création de la notice
25/01/2008 12:48
Dernière modification de la notice
20/08/2019 16:10
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