Origin of segmental identity in the development of the leech nervous system

Détails

ID Serval
serval:BIB_E7646E3F7E3D
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Origin of segmental identity in the development of the leech nervous system
Périodique
Development
Auteur(s)
Shankland  M., Martindale  M. Q., Nardelli-Haefliger  D., Baxter  E., Price  D. J.
ISSN
0950-1991 (Print)
Statut éditorial
Publié
Date de publication
1991
Volume
Suppl 2
Pages
29-38
Notes
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Résumé
The leech embryo develops its segmental body plan by means of a stereotyped cell lineage. Each hemilateral segment arises from a small set of embryonic blast cells via a comparable sequence of formative cell divisions, and for the most part, lineally homologous cells manifest similar patterns of differentiation in the various hemisegments. Nonetheless, some identified central neurons undergo segment-specific or laterally asymmetric patterns of neuropeptide expression and/or cell death. Certain aspects of this regional diversification result from competitive cell interactions which occur at the level of the postmitotic neuron. However, the neuron's segmental identity is lineally determined, being inherited from its blast cell progenitor over several intervening rounds of mitosis. To learn more about the molecular basis of this phenomenon, we have isolated and begun to characterize leech homeobox genes which are related to the genes that govern segmental identity in other organisms.
Mots-clé
Amino Acid Sequence Animals Drosophila/genetics Embryonic Induction/*physiology Genes, Homeobox/genetics Leeches/*embryology/genetics Molecular Sequence Data Nervous System/*embryology Neurons/*cytology Sequence Homology, Amino Acid Stem Cells/*cytology
Pubmed
Création de la notice
25/01/2008 14:35
Dernière modification de la notice
20/08/2019 16:10
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