Microtubule-associated protein 1a is involved in the early development of the rat spinal cord.

Détails

ID Serval
serval:BIB_E75AB621F40F
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Microtubule-associated protein 1a is involved in the early development of the rat spinal cord.
Périodique
Neuroscience Letters
Auteur(s)
Oudega M., Touri F., Deenen M.G., Riederer B.M., Marani E.
ISSN
0304-3940 (Print)
ISSN-L
0304-3940
Statut éditorial
Publié
Date de publication
1998
Volume
246
Numéro
2
Pages
81-84
Langue
anglais
Résumé
The expression of microtubule-associated protein 1a (MAP1a) in the developing rat spinal cord was studied using the monoclonal antibody BW6. Immunoblots of microtubule preparations revealed the presence of MAP1a in spinal cord tissue of rats aged embryonal day 16 and postnatal day 0. The spinal cord matrix layer, between embryonal days 12-17, displayed a pattern of MAP1a-positive processes, horizontally oriented in between the membrane limitans interna and externa. The mantle layer stained intensely for MAP1a between embryonal day 12 and postnatal day 2. MAP1a was found in neuronal cell bodies, axons and dendrites, located mainly in the ventral and intermediate mantle layer. In the marginal layer, MAP1a-positive axons could be observed between embryonal days 14-18. During further development, the intensity of the MAP1a staining in the spinal columns gradually decreased. These expression patterns indicate an involvement of MAP1a in the proliferation and differentiation of neuroblasts, and the maturation of the long spinal fiber systems, i.e. early events in spinal cord development
Mots-clé
Aging/metabolism, Animals, Animals, Newborn, Embryonic and Fetal Development, Gene Expression Regulation, Developmental, Gestational Age, Immunohistochemistry, Microtubule-Associated Proteins/biosynthesis, Rats, Rats, Wistar, Spinal Cord/embryology, Spinal Cord/growth & development
Pubmed
Web of science
Création de la notice
24/01/2008 14:34
Dernière modification de la notice
20/08/2019 16:10
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