UniProt-Related Documents (UniReD): assisting wet lab biologists in their quest on finding novel counterparts in a protein network.

Détails

ID Serval
serval:BIB_E710562FE5F4
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
UniProt-Related Documents (UniReD): assisting wet lab biologists in their quest on finding novel counterparts in a protein network.
Périodique
NAR genomics and bioinformatics
Auteur⸱e⸱s
Theodosiou T., Papanikolaou N., Savvaki M., Bonetto G., Maxouri S., Fakoureli E., Eliopoulos A.G., Tavernarakis N., Amoutzias G.D., Pavlopoulos G.A., Aivaliotis M., Nikoletopoulou V., Tzamarias D., Karagogeos D., Iliopoulos I.
ISSN
2631-9268 (Electronic)
ISSN-L
2631-9268
Statut éditorial
Publié
Date de publication
03/2020
Peer-reviewed
Oui
Volume
2
Numéro
1
Pages
lqaa005
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: epublish
Résumé
The in-depth study of protein-protein interactions (PPIs) is of key importance for understanding how cells operate. Therefore, in the past few years, many experimental as well as computational approaches have been developed for the identification and discovery of such interactions. Here, we present UniReD, a user-friendly, computational prediction tool which analyses biomedical literature in order to extract known protein associations and suggest undocumented ones. As a proof of concept, we demonstrate its usefulness by experimentally validating six predicted interactions and by benchmarking it against public databases of experimentally validated PPIs succeeding a high coverage. We believe that UniReD can become an important and intuitive resource for experimental biologists in their quest for finding novel associations within a protein network and a useful tool to complement experimental approaches (e.g. mass spectrometry) by producing sorted lists of candidate proteins for further experimental validation. UniReD is available at http://bioinformatics.med.uoc.gr/unired/.
Pubmed
Web of science
Open Access
Oui
Création de la notice
04/06/2024 10:53
Dernière modification de la notice
05/06/2024 9:07
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