Sexual dimorphism in the mouse hypothalamic-pituitary-adrenal axis function after endotoxin and insulin stresses during development

Détails

ID Serval
serval:BIB_E6ED60606DE3
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Sexual dimorphism in the mouse hypothalamic-pituitary-adrenal axis function after endotoxin and insulin stresses during development
Périodique
Neuroimmunomodulation
Auteur(s)
Spinedi  E., Chisari  A., Pralong  F., Gaillard  R. C.
ISSN
1021-7401 (Print)
Statut éditorial
Publié
Date de publication
04/1997
Volume
4
Numéro
2
Pages
77-83
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Mar-Apr
Résumé
Bidirectional communication between the immune and the endocrine systems is now widely accepted as essential for the survival of the organism. Since a classical nonresponsive period of the hypothalamic-pituitary-adrenal (HPA) axis takes place shortly after birth and because endogenous sex hormones modulate immune function, the aim of the present work was to determine whether sex steroids regulate the PHA axis response to immune (bacterial, lipopolysaccharide, LPS) and nonimmune (insulin, INS) stressors in mice during development. For this purpose 7-, 15-, 30-, 45- and 60-day-old mice of both sexes were intraperitoneally injected with either vehicle alone (basal) or containing LPS (2 mg/kg body weight) or INS (12 IU/kg body weight). The animals were then killed by decapitation, 2 h or 45 min after LPS or INS, respectively. Plasma samples were assayed to measure corticosterone concentrations. The results indicated that: (a) there was a transient increase in basal plasma corticosterone levels during development, with a peak value at the juvenile age, regardless of sex; (b) a higher basal plasma corticosterone concentration in females than in males characterized the adult age; (c) the infantile age is a period of the HPA axis function nonresponsive to purely neuroendocrine but not to inflammatory stimuli; (d) during the juvenile age, females showed a hyporesponsive HPA axis to neurendocrine and immune stress, whereas male mice were fully unresponsive to both challenges; (e) animals of both sexes showed a maximal HPA axis response to purely neuroendocrine stress at the prepubertal age; this response to the immune stimulus was also maximal in 30-day-old males, while it was found in females after puberty (45-day-old mice); (f) sexual dimorphism in the HPA axis response to a purely neuroendocrine stimulus was found at 30 days of age or later, while this characteristic of the response to endotoxin was not present until puberty. These data clearly suggest that these are gender-dependent characteristics of the ontogeny of the HPA and HP-gonadal axes that are responsible for the sexual dimorphism of HPA axis function in mice.
Mots-clé
Animals Endotoxins/*pharmacology Female Glucocorticoids/blood Growth/*drug effects Hypothalamo-Hypophyseal System/drug effects/*physiology Insulin/*pharmacology Male Mice Mice, Inbred BALB C Pituitary-Adrenal System/drug effects/*physiology Pregnancy *Sex Characteristics Stress/chemically induced
Pubmed
Web of science
Création de la notice
25/01/2008 16:26
Dernière modification de la notice
20/08/2019 16:10
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