Determinants of HIV-1 broadly neutralizing antibody induction.

Détails

ID Serval
serval:BIB_E6B22356AA9D
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Determinants of HIV-1 broadly neutralizing antibody induction.
Périodique
Nature medicine
Auteur⸱e⸱s
Rusert P., Kouyos R.D., Kadelka C., Ebner H., Schanz M., Huber M., Braun D.L., Hozé N., Scherrer A., Magnus C., Weber J., Uhr T., Cippa V., Thorball C.W., Kuster H., Cavassini M., Bernasconi E., Hoffmann M., Calmy A., Battegay M., Rauch A., Yerly S., Aubert V., Klimkait T., Böni J., Fellay J., Regoes R.R., Günthard H.F., Trkola A.
Collaborateur⸱rice⸱s
Swiss HIV Cohort Study
Contributeur⸱rice⸱s
Bucher H.C., Ciuffi A., Dollenmaier G., Egger M., Elzi L., Fehr J., Furrer H., Fux C.A., Haerry D., Hasse B., Hirsch H.H., Hösli I., Kahlert C., Kaiser L., Keiser O., Kovari H., Ledergerber B., Martinetti G., de Tejada B.M., Marzolini C., Metzner K.J., Müller N., Nicca D., Pantaleo G., Paioni P., Rudin C., Schmid P., Speck R., Stöckle M., Tarr P., Vernazza P., Wandeler G., Weber R.
ISSN
1546-170X (Electronic)
ISSN-L
1078-8956
Statut éditorial
Publié
Date de publication
11/2016
Peer-reviewed
Oui
Volume
22
Numéro
11
Pages
1260-1267
Langue
anglais
Notes
Publication types: Journal Article ; Observational Study
Publication Status: ppublish
Résumé
Broadly neutralizing antibodies (bnAbs) are a focal component of HIV-1 vaccine design, yet basic aspects of their induction remain poorly understood. Here we report on viral, host and disease factors that steer bnAb evolution using the results of a systematic survey in 4,484 HIV-1-infected individuals that identified 239 bnAb inducers. We show that three parameters that reflect the exposure to antigen-viral load, length of untreated infection and viral diversity-independently drive bnAb evolution. Notably, black participants showed significantly (P = 0.0086-0.038) higher rates of bnAb induction than white participants. Neutralization fingerprint analysis, which was used to delineate plasma specificity, identified strong virus subtype dependencies, with higher frequencies of CD4-binding-site bnAbs in infection with subtype B viruses (P = 0.02) and higher frequencies of V2-glycan-specific bnAbs in infection with non-subtype B viruses (P = 1 × 10(-5)). Thus, key host, disease and viral determinants, including subtype-specific envelope features that determine bnAb specificity, remain to be unraveled and harnessed for bnAb-based vaccine design.

Mots-clé
AIDS Vaccines, African Continental Ancestry Group, Antibodies, Neutralizing/immunology, Antigens, CD4/immunology, Drug Discovery, European Continental Ancestry Group, Female, Genetic Variation, HIV Antibodies/immunology, HIV Infections/immunology, HIV-1/genetics, HIV-1/immunology, Humans, Linear Models, Longitudinal Studies, Male, Multivariate Analysis, Polysaccharides/immunology, Prospective Studies, RNA, Viral/blood, Switzerland, Time Factors, Viral Load
Pubmed
Web of science
Création de la notice
29/09/2016 17:37
Dernière modification de la notice
20/08/2019 16:09
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