Neuropathie subaiguë, cancers multiples et syndrome de Gougerot-Sjögren: intérêt des anticorps anti-Hu [Subacute neuropathy, multiple cancers, and Gougerot-Sjögren syndrome: contribution of anti-Hu antibody].

Détails

ID Serval
serval:BIB_E6395F3786B0
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Etude de cas (case report): rapporte une observation et la commente brièvement.
Collection
Publications
Titre
Neuropathie subaiguë, cancers multiples et syndrome de Gougerot-Sjögren: intérêt des anticorps anti-Hu [Subacute neuropathy, multiple cancers, and Gougerot-Sjögren syndrome: contribution of anti-Hu antibody].
Périodique
Revue Neurologique
Auteur(s)
Auf G., Benyahia B., Orcel B., Beigelman C., Delattre J.Y.
ISSN
0035-3787 (Print)
ISSN-L
0035-3787
Statut éditorial
Publié
Date de publication
2001
Volume
157
Numéro
2
Pages
219-221
Langue
français
Notes
Publication types: Case Reports ; English Abstract ; Journal Article
Résumé
We report the case of a patient presenting a subacute, predominantly sensory neuropathy. The work up revealed a Sjögren's syndrome and a breast carcinoma. The presence of anti-Hu antibodies, identified by Western Blot using purified recombinant HuD protein, and the absence of the Hu antigen in the breast carcinoma ruled out the responsibility of the Sjögren's syndrome or breast carcinoma. In this context, the most likely diagnosis was a subacute neuropathy associated with small cell lung cancer, which was indeed discovered 3 years later.
Mots-clé
Aged, Autoantibodies/analysis, Breast Neoplasms/immunology, Breast Neoplasms/pathology, Carcinoma, Small Cell/pathology, Female, Hu Paraneoplastic Encephalomyelitis Antigens, Humans, Lung Neoplasms/immunology, Lung Neoplasms/pathology, Neoplasms, Multiple Primary/complications, Neoplasms, Multiple Primary/diagnosis, Nerve Tissue Proteins/analysis, Nerve Tissue Proteins/immunology, Nervous System Diseases/complications, Nervous System Diseases/diagnosis, RNA-Binding Proteins/analysis, RNA-Binding Proteins/immunology, Sjogren's Syndrome/complications, Sjogren's Syndrome/diagnosis
Pubmed
Création de la notice
31/08/2011 12:46
Dernière modification de la notice
20/08/2019 16:09
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