HLA-Bw4 homozygosity is associated with an impaired CD4 T cell recovery after initiation of antiretroviral therapy.

Rauch, A.; Nolan, D.; Furrer, H.; McKinnon, E.; John, M.; Mallal, S.; Gaudieri, S.; Günthard, H.F.; Schmid, P.; Battegay, M.; Hirschel, B.; Telenti, A.; James, I.

doi:10.1086/588479

HLA-Bw4 homozygosity is associated with an impaired CD4 T cell recovery after initiation of antiretroviral therapy.

Détails

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Etat: Public
Version: Final published version
Licence: Non spécifiée
It was possible to publish this article open access thanks to a Swiss National Licence with the publisher.

ID Serval

serval:BIB_E5F87C69D48A

Type

Article: article d'un périodique ou d'un magazine.

Collection

Publications

Institution

UNIL/CHUV

Titre

HLA-Bw4 homozygosity is associated with an impaired CD4 T cell recovery after initiation of antiretroviral therapy.

Périodique

Clinical Infectious Diseases

Auteur⸱e⸱s

Rauch A., Nolan D., Furrer H., McKinnon E., John M., Mallal S., Gaudieri S., Günthard H.F., Schmid P., Battegay M., Hirschel B., Telenti A., James I.

Collaborateur⸱rice⸱s

Swiss HIV Cohort Study

Contributeur⸱rice⸱s

Battegay M., Bernasconi E., Böni J., Bucher HC., Bürgisser P., Calmy A., Cattacin S., Cavassini M., Dubs R., Egger M., Elzi L., Erb P., Fischer M., Flepp M., Fontana A., Francioli P., Furrer H., Fux C., Gorgievski M., Günthard H., Hirsch H., Hirschel B., Hösli I., Kahlert Ch., Kaiser L., Karrer U., Kind C., Klimkait T., Ledergerber B., Martinetti G., Martinez B., Müller N., Nadal D., Opravil M., Paccaud F., Pantaleo G., Rauch A., Regenass S., Rickenbach M., Rudin C., Schmid P., Schultze D., Schüpbach J., Speck R., Taffé P., Tarr P., Telenti A., Trkola A., Vernazza P., Weber R., Yerly S.

ISSN

1537-6591 (Electronic)

ISSN-L

1058-4838

Statut éditorial

Publié

Date de publication

06/2008

Peer-reviewed

Oui

Volume

Numéro

Pages

1921-1925

Langue

anglais

Notes

Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish

Résumé

We assessed the influence of human leukocyte antigen (HLA) alleles HLA-Bw4 and HLA-Bw6 on CD4 T cell recovery after starting successful combination antiretroviral therapy in 265 individuals. The median gains in the CD4 T cell count after 4 years were 258 cells/microL for HLA-Bw4 homozygotes, 321 cells/microL for HLA-Bw4/Bw6 heterozygotes, and 363 cells/microL for HLA-Bw6 homozygotes (P = .01, compared with HLA-Bw4 homozygotes). HLA-Bw4 homozygosity appears to predict an impaired CD4 T cell recovery after initiation of combination antiretroviral therapy.

Mots-clé

Adult, Aged, Aged, 80 and over, Antiretroviral Therapy, Highly Active, CD4 Lymphocyte Count, CD4-Positive T-Lymphocytes/immunology, Female, HIV Infections/drug therapy, HIV Infections/genetics, HLA-B Antigens/genetics, Homozygote, Humans, Male, Middle Aged

URN

urn:nbn:ch:serval-BIB_E5F87C69D48A4

OAI-PMH

oai:serval.unil.ch:BIB_E5F87C69D48A

DOI

10.1086/588479

Pubmed

18466093

Web of science

000256044900024

Open Access

Oui