Diagnostic value of antibody-induced procoagulant platelets in heparin-induced thrombocytopenia: communication from the ISTH SSC Subcommittee on Platelet Immunology.
Détails
ID Serval
serval:BIB_E5AA0EC16B85
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Diagnostic value of antibody-induced procoagulant platelets in heparin-induced thrombocytopenia: communication from the ISTH SSC Subcommittee on Platelet Immunology.
Périodique
Journal of thrombosis and haemostasis
Collaborateur⸱rice⸱s
SSC Platelet Immunology of the ISTH
Contributeur⸱rice⸱s
Nazy I., Al-Samkari H., McKenzie S., Pouplard C., Sharma R.
ISSN
1538-7836 (Electronic)
ISSN-L
1538-7836
Statut éditorial
Publié
Date de publication
03/2024
Peer-reviewed
Oui
Volume
22
Numéro
3
Pages
860-868
Langue
anglais
Notes
Publication types: Practice Guideline
Publication Status: ppublish
Publication Status: ppublish
Résumé
Heparin-induced thrombocytopenia (HIT) is an immune-mediated prothrombotic disorder characterized by a drop in platelet count and an increased risk of thromboembolic events. The accurate diagnosis of HIT involves clinical assessment and laboratory testing with well-characterized functional tests. Recent research has shown the potential of investigating procoagulant platelet formation induced by HIT antibodies. To successfully implement these assays in clinical laboratories, careful consideration of technical and preanalytical factors is crucial. In this communication from the SSC Platelet Immunology, we provide a consensus from experts on the use of flow cytometry in HIT diagnosis, highlighting the importance of standardized protocols.
Mots-clé
Humans, Heparin/adverse effects, Thrombocytopenia/chemically induced, Thrombocytopenia/diagnosis, Blood Platelets, Platelet Count, Antibodies, Communication, Platelet Factor 4, blood platelets, diagnostic tests routine, flow cytometry, heparin, platelet activation
Pubmed
Web of science
Open Access
Oui
Création de la notice
15/12/2023 10:20
Dernière modification de la notice
13/04/2024 7:04