Measurement of β-tryptase in postmortem serum, pericardial fluid, urine and vitreous humor in the forensic setting.

Détails

ID Serval
serval:BIB_E5540A1D5C31
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Measurement of β-tryptase in postmortem serum, pericardial fluid, urine and vitreous humor in the forensic setting.
Périodique
Forensic Science International
Auteur(s)
Comment L., Reggiani Bonetti L., Mangin P., Palmiere C.
ISSN
1872-6283 (Electronic)
ISSN-L
0379-0738
Statut éditorial
Publié
Date de publication
2014
Peer-reviewed
Oui
Volume
240
Pages
29-34
Langue
anglais
Notes
Publication types: Journal Article
Résumé
In the realm of forensic pathology, β-tryptase measurement for diagnostic purposes is performed in postmortem serum obtained from femoral blood. This may be partially or completely unavailable in some specific cases, such as infant autopsies and severely damaged bodies. The aim of this study was to investigate the usefulness of determining β-tryptase levels for diagnostic purposes in alternative biological samples. Urine, vitreous humor and pericardial fluid were selected and measured in 94 subjects including: fatal anaphylaxis following contrast material administration (6 cases), hypothermia (10 cases), diabetic ketoacidosis (10 cases), gunshot suicide (10 cases), heroin injection-related deaths (18 cases), trauma (10 cases), sudden death with minimal coronary atherosclerosis (10 cases), severe coronary atherosclerosis without myocardial infarction (10 cases) and severe coronary atherosclerosis with myocardial infarction (10 cases). Postmortem serum and pericardial fluid β-tryptase levels higher than the clinical reference value (11.4ng/ml) were systematically identified in fatal anaphylaxis following contrast material administration and 6 cases unrelated to anaphylaxis. β-tryptase concentrations in urine and vitreous humor were lower than the clinical reference value in all cases included in this study. Determination of β-tryptase in pericardial fluid appears to be a possible alternative to postmortem serum in the early postmortem period when femoral blood cannot be collected during autopsy and biochemical investigations are required to objectify increased β-tryptase levels.
Mots-clé
Anaphylaxis, Beta-tryptase, Forensic pathology, Mast cells, Pericardial fluid, Postmortem biochemistry
Pubmed
Web of science
Création de la notice
06/05/2014 13:21
Dernière modification de la notice
20/08/2019 16:08
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