Publication bias in animal research: a systematic review protocol.

Détails

Ressource 1Télécharger: BIB_E5489DE81118.P001.pdf (153.60 [Ko])
Etat: Public
Version: de l'auteur
ID Serval
serval:BIB_E5489DE81118
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Publication bias in animal research: a systematic review protocol.
Périodique
Systematic Reviews
Auteur(s)
Briel M., Mûller K.F., Meerpohl J.J., von Elm E., Lang B., Motschall E., Gloy V., Lamontagne F., Schwarzer G., Bassler D.
Collaborateur(s)
OPEN Consortium
ISSN
2046-4053 (Electronic)
ISSN-L
2046-4053
Statut éditorial
Publié
Date de publication
2013
Volume
2
Pages
23
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov'tPublication Status: epublish; PDF : protocol
Résumé
BACKGROUND: Systematic reviews and meta-analyses of pre-clinical studies, in vivo animal experiments in particular, can influence clinical care. Publication bias is one of the major threats of validity in systematic reviews and meta-analyses. Previous empirical studies suggested that systematic reviews and meta-analyses have become more prevalent until 2010 and found evidence for compromised methodological rigor with a trend towards improvement. We aim to comprehensively summarize and update the evidence base on systematic reviews and meta-analyses of animal studies, their methodological quality and assessment of publication bias in particular.
METHODS/DESIGN: The objectives of this systematic review are as follows: âeuro¢To investigate the epidemiology of published systematic reviews of animal studies until present. âeuro¢To examine methodological features of systematic reviews and meta-analyses of animal studies with special attention to the assessment of publication bias. âeuro¢To investigate the influence of systematic reviews of animal studies on clinical research by examining citations of the systematic reviews by clinical studies. Eligible studies for this systematic review constitute systematic reviews and meta-analyses that summarize in vivo animal experiments with the purpose of reviewing animal evidence to inform human health. We will exclude genome-wide association studies and animal experiments with the main purpose to learn more about fundamental biology, physical functioning or behavior. In addition to the inclusion of systematic reviews and meta-analyses identified by other empirical studies, we will systematically search Ovid Medline, Embase, ToxNet, and ScienceDirect from 2009 to January 2013 for further eligible studies without language restrictions. Two reviewers working independently will assess titles, abstracts, and full texts for eligibility and extract relevant data from included studies. Data reporting will involve a descriptive summary of meta-analyses and systematic reviews.
DISCUSSION: Results are expected to be publicly available later in 2013 and may form the basis for recommendations to improve the quality of systematic reviews and meta-analyses of animal studies and their use with respect to clinical care.
Pubmed
Open Access
Oui
Création de la notice
22/09/2013 22:40
Dernière modification de la notice
20/08/2019 16:08
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