D-JNKI-1 treatment prevents the progression of hearing loss in a model of cochlear implantation trauma

Détails

ID Serval
serval:BIB_E5354437574D
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
D-JNKI-1 treatment prevents the progression of hearing loss in a model of cochlear implantation trauma
Périodique
Otology and Neurotology
Auteur⸱e⸱s
Eshraghi  A. A., He  J., Mou  C. H., Polak  M., Zine  A., Bonny  C., Balkany  T. J., Van De Water  T. R.
ISSN
1531-7129 (Print)
Statut éditorial
Publié
Date de publication
06/2006
Volume
27
Numéro
4
Pages
504-11
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Jun
Résumé
HYPOTHESES: 1) Hearing loss caused by electrode insertion trauma has both acute and delayed components; and 2) the delayed component of trauma-initiated hearing loss can be prevented by a direct delivery of a peptide inhibitor of the c-Jun N-terminal kinase cell death signal cascade, that is, D-JNKI-1, immediately after the electrode insertion within the cochlea. BACKGROUND: Acute trauma to the macroscopic elements of the cochlea from electrode insertion is well known. The impact of trauma-induced oxidative stress within injured cochlear tissues and the efficacy of drugs (e.g., D-JNKI-1) to prevent apoptosis of damaged hair cells is not well defined. METHODS: Hearing function was tested by pure-tone evoked auditory brainstem responses (ABRs) and distortion products of otoacoustic emissions (DPOAEs). D-JNKI-1 in artificial perilymph (AP) or AP alone was delivered into the scala tympani immediately after electrode trauma and for 7 days. Controls were nontreated contralateral and D-JNKI-1-treated ears without electrode insertion trauma. RESULTS: There was no increase in the hearing thresholds of either the contralateral control ears or in the D-JNKI-1 without trauma animals. There was a progressive increase in ABR thresholds and decrease in DPOAE amplitudes after electrode insertion trauma in untreated and in AP-treated cochleae. Treatment with D-JNKI-1 prevented the progressive increase in ABR thresholds and decrease in DPOAE amplitudes that occur after electrode insertion trauma. CONCLUSION: Hearing loss caused by cochlear implant electrode insertion trauma in guinea pigs has both acute and delayed components. The delayed component can be prevented by treating the cochlea with D-JNKI-1.
Pubmed
Web of science
Création de la notice
25/01/2008 15:16
Dernière modification de la notice
20/08/2019 17:08
Données d'usage