Defective neurogenesis in citron kinase knockout mice by altered cytokinesis and massive apoptosis.

Détails

ID Serval
serval:BIB_E4CDBE4B45F5
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Defective neurogenesis in citron kinase knockout mice by altered cytokinesis and massive apoptosis.
Périodique
Neuron
Auteur(s)
Di Cunto F., Imarisio S., Hirsch E., Broccoli V., Bulfone A., Migheli A., Atzori C., Turco E., Triolo R., Dotto G.P., Silengo L., Altruda F.
ISSN
0896-6273 (Print)
ISSN-L
0896-6273
Statut éditorial
Publié
Date de publication
2000
Volume
28
Numéro
1
Pages
115-127
Langue
anglais
Résumé
Citron-kinase (Citron-K) has been proposed by in vitro studies as a crucial effector of Rho in regulation of cytokinesis. To further investigate in vivo its biologic functions, we have inactivated Citron-K gene in mice by homologous recombination. Citron-K-/- mice grow at slower rates, are severely ataxic, and die before adulthood as a consequence of fatal seizures. Their brains display defective neurogenesis, with depletion of specific neuronal populations. These abnormalities arise during development of the central nervous system due to altered cytokinesis and massive apoptosis. Our results indicate that Citron-K is essential for cytokinesis in vivo but only in specific neuronal precursors. Moreover, they suggest a novel molecular mechanism for a subset of human malformative syndromes of the CNS.
Mots-clé
Animals, Apoptosis/genetics, Ataxia/etiology, Brain/embryology, Brain/pathology, Cell Division/genetics, Cyclin D1/metabolism, DNA/biosynthesis, Intracellular Signaling Peptides and Proteins, Mice, Mice, Knockout, Neurodegenerative Diseases/complications, Neurodegenerative Diseases/genetics, Neurons/metabolism, Neurons/pathology, Polyploidy, Protein-Serine-Threonine Kinases/biosynthesis, Protein-Serine-Threonine Kinases/deficiency, Seizures/etiology, Stem Cells/metabolism, Stem Cells/pathology, rho-Associated Kinases
Pubmed
Web of science
Open Access
Oui
Création de la notice
24/01/2008 14:58
Dernière modification de la notice
20/08/2019 16:08
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