Is there a correlation between raised erythropoietin and thrombotic events in sickle-cell anaemia?

Détails

ID Serval
serval:BIB_E4CC7F7A3065
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Is there a correlation between raised erythropoietin and thrombotic events in sickle-cell anaemia?
Périodique
Lancet
Auteur(s)
Dale G.L., Alberio L.
ISSN
0140-6736 (Print)
ISSN-L
0140-6736
Statut éditorial
Publié
Date de publication
1998
Peer-reviewed
Oui
Volume
352
Numéro
9127
Pages
566-567
Langue
anglais
Notes
Publication types: Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S.
Résumé
Children with sickle-cell anaemia are predisposed to thrombotic strokes, the aetiology of which is unclear. We propose that erythropoietin, produced in response to chronic anaemia, is responsible for changes in platelet reactivity with a resulting increase in thromboses. This hypothesis is based on reports of enhanced aggregability of erythropoietin-driven platelets and an increased rate of thrombosis in patients receiving large doses of recombinant erythropoietin. Experiments in animals have shown that erythropoietin stimulates synthesis of platelets, that erythropoietin-driven platelets are hyper-reactive compared with age-matched control platelets, and that erythropoietin is pro-thrombotic. These data suggest that erythropoietin-dependent changes in platelet reactivity may potentiate thrombosis in sickle-cell anaemia, particularly in children who, compared with adults, have markedly higher erythropoietin concentrations and incidence of strokes.
Mots-clé
Adult, Anemia, Sickle Cell/blood, Anemia, Sickle Cell/complications, Animals, Case-Control Studies, Cerebrovascular Disorders/etiology, Child, Erythropoietin/administration & dosage, Erythropoietin/adverse effects, Erythropoietin/</QualifierName> <QualifierName MajorTopicYN="N" UI="Q000627">, Humans, Platelet Activation/physiology, Platelet Aggregation/physiology, Recombinant Proteins, Thrombosis/etiology
Pubmed
Web of science
Création de la notice
10/02/2015 11:07
Dernière modification de la notice
20/08/2019 16:08
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