Hind limb ischemia in rabbit model: T2-prepared versus time-of-flight MR angiography at 3 T.

Détails

ID Serval
serval:BIB_E4C5A4F7C3C7
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Hind limb ischemia in rabbit model: T2-prepared versus time-of-flight MR angiography at 3 T.
Périodique
Radiology
Auteur(s)
Korosoglou G., Gilson W.D., Schär M., Ustun A., Hofmann L.V., Kraitchman D.L., Stuber M.
ISSN
1527-1315[electronic], 0033-8419[linking]
Statut éditorial
Publié
Date de publication
2007
Volume
245
Numéro
3
Pages
761-769
Langue
anglais
Notes
Publication types: Comparative Study ; Journal Article ; Research Support, N.I.H., Extramural
Publication Status: ppublish
Résumé
PURPOSE: To prospectively compare various parameters of vessels imaged at 3 T by using time-of-flight (TOF) and T2-prepared magnetic resonance (MR) angiography in a rabbit model of hind limb ischemia. MATERIALS AND METHODS: Experiments were approved by the institutional animal care and use committee. Endovascular occlusion of the left superficial femoral artery was induced in 14 New Zealand white rabbits. After 2 weeks, MR angiography and conventional (x-ray) angiography were performed. Vessel sharpness was evaluated visually in the ischemic and nonischemic limbs, and the presence of small collateral vessels was evaluated in the ischemic limbs. Vessel sharpness was also quantified by evaluating the magnitude of signal intensity change at the vessel borders. RESULTS: The sharpness of vessels in the nonischemic limbs was similar between the TOF and the T2-prepared images. In the ischemic limbs, however, T2-prepared imaging, as compared with TOF imaging, generated higher vessel sharpness in arteries with diminished blood flow (mean vessel sharpness: 44% vs 30% for popliteal arteries, 45% vs 28% for saphenous arteries; P < .001 for both comparisons) and enabled better detection of small collateral vessels (93% vs 36% of vessels, P < .001). CONCLUSION: T2-prepared imaging can facilitate high-spatial-resolution MR angiography of small vessels with low blood flow and thus has potential as a tool for noninvasive evaluation of arteriogenic therapies, without use of contrast material. Supplemental material: http://radiology.rsnajnls.org/cgi/content/full/2452062067/DC1.
Mots-clé
Animals, Hindlimb/blood supply, Ischemia/diagnosis, Magnetic Resonance Angiography/methods, Rabbits
Pubmed
Web of science
Création de la notice
02/03/2010 16:04
Dernière modification de la notice
20/08/2019 16:08
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