The effect of a single dose of escitalopram on sensorimotor networks.

Détails

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Etat: Public
Version: Final published version
ID Serval
serval:BIB_E4B45C938200
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
The effect of a single dose of escitalopram on sensorimotor networks.
Périodique
Brain and behavior
Auteur⸱e⸱s
Weisstanner C., Kägi G., Krammer W., Eap C.B., Wiest R., Missimer J.H., Weder B.J.
ISSN
2162-3279 (Electronic)
Statut éditorial
Publié
Date de publication
06/2018
Peer-reviewed
Oui
Volume
8
Numéro
6
Pages
e00975
Langue
anglais
Notes
Publication types: Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
Serving as a pilot study of poststroke pharmacotherapy, the present investigation was intended to establish the effect of a single dose of escitalopram on motor task performance in normal volunteers.
Ten healthy volunteers of median age 63 years including four females performed a well-studied tactile manipulation task in two fMRI sessions using a double-blind cross-over design. The sessions began approximately three hours after ingestion of 20 mg escitalopram or placebo presented in pseudorandom order. The fMRI image sequences were submitted to principal component analysis (PCA).
Based on volume correlations of task-related principal components with the mean component images derived in our previous study, we established the reproducibility of two networks of sensorimotor activity proposed there. The network reflecting motor control (cerebral pattern I) appeared invariably in placebo and verum conditions. In contrast, the other network, attributed to diminished motor control due to distracting mental processing (cerebral pattern II), emerged less regularly and exhibited more variability. Second-level PCAs of both conditions confirmed the findings of the initial analysis. Specifically, it validated the dominant and invariable expression of cerebral pattern I after application of a single dose of escitalopram. Dynamic causal modeling confirmed enhanced motor output as a result of a significantly increased connectivity between primary motor cortex and dorsal premotor cortex.
This pilot study suggests the promise of stimulation by a specific serotonin reuptake inhibitor in regard to recovery and preservation of motor control after stroke.
Mots-clé
Citalopram/administration & dosage, Citalopram/pharmacokinetics, Dose-Response Relationship, Drug, Double-Blind Method, Female, Healthy Volunteers, Humans, Male, Middle Aged, Pilot Projects, Principal Component Analysis, Psychomotor Performance/drug effects, Reproducibility of Results, Sensorimotor Cortex/drug effects, Serotonin Uptake Inhibitors/administration & dosage, Serotonin Uptake Inhibitors/pharmacokinetics, Stroke/drug therapy, Stroke/physiopathology, dynamic causal modeling, escitalopram, fMRI, motor control, principal component analysis, sensorimotor networks
Pubmed
Web of science
Open Access
Oui
Création de la notice
03/09/2018 9:59
Dernière modification de la notice
21/11/2022 8:27
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