A role for spindles in the onset of rapid eye movement sleep.

Détails

Ressource 1Télécharger: Bandarabadi_Spindle_NatComm.pdf (4306.01 [Ko])
Etat: Public
Version: Final published version
Licence: CC BY 4.0
ID Serval
serval:BIB_E42CDAA76A85
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
A role for spindles in the onset of rapid eye movement sleep.
Périodique
Nature communications
Auteur(s)
Bandarabadi Mojtaba, Herrera C.G., Gent T.C., Bassetti C., Schindler K., Adamantidis A.R.
ISSN
2041-1723 (Electronic)
ISSN-L
2041-1723
Statut éditorial
Publié
Date de publication
16/10/2020
Peer-reviewed
Oui
Volume
11
Numéro
1
Pages
5247
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: epublish
Résumé
Sleep spindle generation classically relies on an interplay between the thalamic reticular nucleus (TRN), thalamo-cortical (TC) relay cells and cortico-thalamic (CT) feedback during non-rapid eye movement (NREM) sleep. Spindles are hypothesized to stabilize sleep, gate sensory processing and consolidate memory. However, the contribution of non-sensory thalamic nuclei in spindle generation and the role of spindles in sleep-state regulation remain unclear. Using multisite thalamic and cortical LFP/unit recordings in freely behaving mice, we show that spike-field coupling within centromedial and anterodorsal (AD) thalamic nuclei is as strong as for TRN during detected spindles. We found that spindle rate significantly increases before the onset of rapid eye movement (REM) sleep, but not wakefulness. The latter observation is consistent with our finding that enhancing spontaneous activity of TRN cells or TRN-AD projections using optogenetics increase spindle rate and transitions to REM sleep. Together, our results extend the classical TRN-TC-CT spindle pathway to include non-sensory thalamic nuclei and implicate spindles in the onset of REM sleep.
Mots-clé
Animals, Electroencephalography, Eye/chemistry, Female, Male, Memory, Mice, Inbred C57BL, Ocular Physiological Phenomena, Optogenetics, Sleep, REM, Thalamic Nuclei/chemistry, Thalamic Nuclei/physiology, Thalamus/chemistry, Thalamus/physiology, Wakefulness
Pubmed
Web of science
Open Access
Oui
Création de la notice
23/11/2020 15:36
Dernière modification de la notice
07/07/2021 6:13
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