The introduction of balloon angioplasty represents the major step in modern cardiology. Today four different techniques for interventional treatment of coronary artery disease are at our disposition for classic balloon angioplasty, laser balloon, catheter atheromectomy and endovascular prosthesis make interventions in coronary artery disease more easy and reliable. However, the main problem, restenosis, which appears in one fourth of the cases, is not yet resolved. We report our experience in 1000 cases of transluminal approach to coronary artery disease.