cAMP-dependent ACTH secretagogues facilitate corticotropin releasing activity of angiotensin II on rat anterior pituitary cells in vitro

Détails

ID Serval
serval:BIB_E3FF5E3BA5D3
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
cAMP-dependent ACTH secretagogues facilitate corticotropin releasing activity of angiotensin II on rat anterior pituitary cells in vitro
Périodique
Acta Endocrinologica
Auteur⸱e⸱s
Schoenenberg  P., Gaillard  R. C., Kehrer  P., Muller  A. F.
ISSN
0001-5598 (Print)
Statut éditorial
Publié
Date de publication
01/1987
Volume
114
Numéro
1
Pages
118-23
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Jan
Résumé
Both arginine vasopressin (AVP) and angiotensin II (AII) potentiate the corticotropin-releasing activity of CRF41 via a potentiation of CRF41-induced cAMP production. In perfused rat anterior pituitary cells, AII (10(-8) mol) showed a transitory 2-fold increase in its ACTH-releasing activity, when tested after application extract of rat stalk median eminence. In order to determine whether this facilitating effect on AII corticotropin-releasing activity occurred through cAMP-dependent mechanisms, the ACTH-releasing activity of AII was tested after stimulation with CRF41, AVP or forskolin, three secretagogues with known effects on cAMP production. When given 16 min after CRF41, 10 micrograms/l, AII (10(-8) mol) showed a significant increase (210%) in its ACTH-releasing activity, which returned to the normal level when AII-stimulation was repeated at 32 min (121%) and 48 min (100%). Similarly, forskolin, 3 X 10(-6) mol, produced a significant transitory increase (208%) in the subsequent AII-induced ACTH release whereas AVP, 10 micrograms/l and 100 micrograms/l, had no effect on the following ACTH response to AII. These results suggest that the AII-induced ACTH secretion--which is cAMP independent--nevertheless may be modulated by previously stimulation of the cAMP pathway.
Mots-clé
Adrenocorticotropic Hormone/*secretion Angiotensin II/*pharmacology Animals Arginine Vasopressin/*pharmacology Biological Assay Corticotropin-Releasing Hormone/metabolism/*pharmacology Cyclic AMP/*biosynthesis Female Median Eminence/analysis Pituitary Gland, Anterior/*drug effects Rats Rats, Inbred Strains Tissue Extracts/administration & dosage
Pubmed
Web of science
Création de la notice
15/02/2008 17:58
Dernière modification de la notice
20/08/2019 17:07
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