PPARgamma expression in normal human placenta, hydatidiform mole and choriocarcinoma
Détails
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Etat: Public
Version: Final published version
Licence: Non spécifiée
It was possible to publish this article open access thanks to a Swiss National Licence with the publisher.
Etat: Public
Version: Final published version
Licence: Non spécifiée
It was possible to publish this article open access thanks to a Swiss National Licence with the publisher.
ID Serval
serval:BIB_E3DAB0862B8B
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
PPARgamma expression in normal human placenta, hydatidiform mole and choriocarcinoma
Périodique
Molecular Human Reproduction
ISSN
1360-9947 (Print)
Statut éditorial
Publié
Date de publication
06/2002
Volume
8
Numéro
6
Pages
574-9
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Jun
Research Support, Non-U.S. Gov't --- Old month value: Jun
Résumé
Peroxisome proliferator-activated receptor (PPAR) gamma belongs to a subclass of nuclear hormone receptors that execute their transcriptional functions as heterodimers with the retinoid X receptors (RXR). PPARgamma plays a pivotal role in cellular differentiation. This study investigated PPARgamma protein expression in normal human placentas, hydatidiform moles and choriocarcinoma, using immunohistochemical and Western blot analyses. In first trimester normal placenta, PPARgamma was mainly localized in the nuclei of the villous cytotrophoblastic cells, whereas at term it was mainly localized in the nuclei of the syncytiotrophoblast. Extravillous cytotrophoblast of cell islands and cell columns also showed nuclear PPARgamma immunostaining. A striking result was the altered expression patterns of PPARgamma in pathological tissues; PPARgamma showed a reduced immunostaining in the trophoblastic diseases. In hydatidiform moles, PPARgamma was mainly localized in the nuclei of the trophoblastic collections of the pathological villi and in the extravillous trophoblastic cells, whereas in the choriocarcinoma, only a few trophoblastic cells showed weak PPARgamma nuclear immunostaining. These findings suggest an involvement of PPARgamma in trophoblast differentiation during normal placental development. The down-regulation of PPARgamma expression in the gestational trophoblastic diseases analysed in this study provides a new insight into the progression of these pathologies.
Mots-clé
Choriocarcinoma/*metabolism/pathology
DNA-Binding Proteins/genetics/metabolism
Female
Humans
Hydatidiform Mole/*metabolism/pathology
Nuclear Proteins/genetics/metabolism
Placenta/cytology/growth & development/*metabolism
Pregnancy
Pregnancy Trimesters
Receptors, Cytoplasmic and Nuclear/genetics/*metabolism
Transcription Factors/genetics/*metabolism
Uterine Neoplasms/*metabolism/pathology
Pubmed
Web of science
Open Access
Oui
Création de la notice
25/01/2008 9:29
Dernière modification de la notice
14/02/2022 8:57