What impact do systemically administrated bisphosphonates have on oral implant therapy? A systematic review.

Détails

ID Serval
serval:BIB_E3D85F546D1D
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
What impact do systemically administrated bisphosphonates have on oral implant therapy? A systematic review.
Périodique
Clinical Oral Implants Research
Auteur⸱e⸱s
Madrid C., Sanz M.
ISSN
1600-0501[electronic]
Statut éditorial
Publié
Date de publication
2009
Volume
20
Numéro
Suppl. 4
Pages
87-95
Langue
anglais
Notes
Publication types: Journal Article ; Review
Résumé
OBJECTIVES: The aim of this systematic review is to evaluate, analysing the dental literature, whether: * Patients on intravenous (IV) or oral bisphosphonates (BPs) can receive oral implant therapy and what could be the risk of developing bisphosphonate-related osteonecrosis of the jaw (BRONJ)? * Osseointegrated implants could be affected by BP therapy. MATERIAL AND METHODS: A Medline search was conducted and all publications fulfilling the inclusion and exclusion criteria from 1966 until December 2008 were included in the review. Moreover, the Cochrane Data Base of Systematic Reviews, and the Cochrane Central Register of Controlled Trials and EMBASE (from 1980 to December 2008) were searched for English-language articles published between 1966 and 2008. Literature search was completed by a hand research accessing the references cited in all identified publications. RESULTS: The literature search rendered only one prospective and three retrospective studies. The prospective controlled non-randomized clinical study followed patients with and without BP medication up to 36 months after implant therapy. The patients in the experimental group had been on oral BPs before implant therapy for periods ranging between 1 and 4 years. None of the patients developed BRONJ and implant outcome was not affected by the BP medication. The three selected retrospective studies (two case-controls and one case series) yielded very similar results. All have followed patients on oral BPs after implant therapy, with follow-up ranging between 2 and 4 years. BRONJ was never reported and implant survival rates ranged between 95% and 100%. The literature search on BRONJ including guidelines and recommendations found 59 papers, from which six were retrieved. Among the guidelines, there is a consensus on contraindicating implants in cancer patients under IV-BPs and not contraindicating dental implants in patients under oral-BPs for osteoporosis. CONCLUSIONS: From the analysis of the one prospective and the three retrospective series (217 patients), the placement of an implant may be considered a safe procedure in patients taking oral BPs for <5 years with regard to the occurrence of BRONJ since in these studies no BRONJ has been reported. Moreover, the intake of oral-BPs did not influence short-term (1-4 years) implant survival rates.
Mots-clé
Administration, Oral, Animals, Bone Density Conservation Agents/administration & dosage, Bone Density Conservation Agents/adverse effects, Dental Care for Chronically Ill, Dental Implantation, Endosseous, Dental Implants, Dental Restoration Failure, Diphosphonates/administration & dosage, Diphosphonates/adverse effects, Humans, Injections, Intravenous, Jaw Diseases/chemically induced, Osseointegration/drug effects, Osteonecrosis/chemically induced, Practice Guidelines as Topic, Risk
Pubmed
Web of science
Création de la notice
11/12/2009 9:52
Dernière modification de la notice
20/08/2019 16:07
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