Clinical evaluation of a new in-vitro assay for specific IgE, the immuno CAP system
Détails
ID Serval
serval:BIB_E3A8E9B53076
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Clinical evaluation of a new in-vitro assay for specific IgE, the immuno CAP system
Périodique
Clinical and Experimental Allergy
ISSN
0954-7894 (Print)
Statut éditorial
Publié
Date de publication
01/1991
Volume
21
Numéro
1
Pages
127-31
Notes
Comparative Study
Journal Article --- Old month value: Jan
Journal Article --- Old month value: Jan
Résumé
The Pharmacia CAP system is a new assay for specific IgE characterized by a new solid phase (hydrophilic polymer encased in a capsule). The CAP results were compared to those of the Phadebas IgE RAST and skin-prick tests (SPT) performed in 145 subjects suffering from rhinitis and/or asthma with eight common inhalant allergens (total number of tests = 1160). Concording CAP/RAST results were found in 91% of the tests. The CAP was positive in 78% and the RAST in 65% of the positive SPT. Conversely, the CAP was negative in 90.6% and the RAST in 96.4% of the negative SPT. A pattern negative SPT, negative RAST and positive CAP' was found in 56 tests (40 subjects): in four such subjects, the CAP positivity was confirmed by a positive IgE crossed radioimmunoelectrophoresis. Three borderline positive results were found among 240 negative controls (serum from cord blood or non-atopics). These data indicate that compared with SPT the CAP system is (a) more sensitive than the Pharmacia RAST and (b) does not seem less specific.
Mots-clé
Adolescent
Adult
Aged
Female
Humans
Immunoelectrophoresis, Two-Dimensional
Immunoglobulin E/*analysis
*Immunologic Techniques
Male
Middle Aged
Radioallergosorbent Test
Skin Tests
Pubmed
Web of science
Création de la notice
28/01/2008 12:58
Dernière modification de la notice
20/08/2019 17:07