European Association of Neuro-Oncology (EANO) guidelines for treatment of primary central nervous system lymphoma (PCNSL).
Détails
ID Serval
serval:BIB_E39A5D50A7EF
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
European Association of Neuro-Oncology (EANO) guidelines for treatment of primary central nervous system lymphoma (PCNSL).
Périodique
Neuro-oncology
ISSN
1523-5866 (Electronic)
ISSN-L
1522-8517
Statut éditorial
Publié
Date de publication
05/01/2023
Peer-reviewed
Oui
Volume
25
Numéro
1
Pages
37-53
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Publication Status: ppublish
Résumé
The management of primary central nervous system (PCNSL) is one of the most controversial topics in neuro-oncology because of the complexity of the disease and the limited number of controlled studies available. In 2021, given recent advances and the publication of practice-changing randomized trials, the European Association of Neuro-Oncology (EANO) created a multidisciplinary task force to update the previously published evidence-based guidelines for immunocompetent adult patients with PCNSL and added a section on immunosuppressed patients. The guideline provides consensus considerations and recommendations for the treatment of PCNSL, including intraocular manifestations and specific management of the elderly. The main changes from the previous guideline include strengthened evidence for the consolidation with ASCT in first-line treatment, prospectively assessed chemotherapy combinations for both young and elderly patients, clarification of the role of rituximab even though the data remain inconclusive, of the role of new agents, and the incorporation of immunosuppressed patients and primary ocular lymphoma. The guideline should aid the clinicians in everyday practice and decision making and serve as a basis for future research in the field.
Mots-clé
Adult, Humans, Aged, Combined Modality Therapy, Central Nervous System Neoplasms/pathology, Antineoplastic Combined Chemotherapy Protocols, Central Nervous System/pathology, Lymphoma/drug therapy, chemotherapy, immunotherapy, primary CNS lymphoma, radiotherapy, treatment
Pubmed
Web of science
Open Access
Oui
Création de la notice
22/08/2022 13:06
Dernière modification de la notice
19/01/2023 6:53