Oral flurbiprofen metabolic ratio assessment using a single-point dried blood spot.

Détails

ID Serval
serval:BIB_E35B5414653E
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Oral flurbiprofen metabolic ratio assessment using a single-point dried blood spot.
Périodique
Clinical Pharmacology and Therapeutics
Auteur(s)
Daali Y., Samer C., Déglon J., Thomas A., Chabert J., Rebsamen M., Staub C., Dayer P., Desmeules J.
ISSN
1532-6535 (Electronic)
ISSN-L
0009-9236
Statut éditorial
Publié
Date de publication
2012
Peer-reviewed
Oui
Volume
91
Numéro
3
Pages
489-496
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't Publication Status: ppublish
Résumé
We investigated whether a single blood measurement using the minimally invasive technique of a finger prick to draw a blood sample of 5 µl (to yield a dried blood spot (DBS)) is suitable for the assessment of flurbiprofen (FLB) metabolic ratio (MR). Ten healthy volunteers who had been genotyped for CYP2C9 were recruited as subjects. They received FLB alone in session 1 and FLB with fluconazole in session 2. In session 3, the subjects were pretreated for 4 days with rifampicin and received FLB with the last dose of rifampicin on day 5. Plasma and DBS samples were obtained between 0 and 8 h after FLB administration, and urine was collected during the 8 h after administration. The pharmacokinetic profiles of the drugs were comparable in DBS and plasma. FLB's apparent clearance values decreased by 35% in plasma and DBS during session 2 and increased by 75% in plasma and by 30% in DBS during session 3. Good correlations were observed between MRs calculated from urine, plasma, and DBS samples.
Mots-clé
Administration, Oral, Adult, Area Under Curve, Aryl Hydrocarbon Hydroxylases/antagonists & inhibitors, Aryl Hydrocarbon Hydroxylases/genetics, Cytochrome P-450 CYP2C9, Dried Blood Spot Testing/methods, Fluconazole/administration & dosage, Flurbiprofen/blood, Flurbiprofen/pharmacokinetics, Genotype, Humans, Hydrolysis, Male, Rifampin/administration & dosage, Young Adult
Pubmed
Web of science
Création de la notice
23/02/2015 15:19
Dernière modification de la notice
20/08/2019 16:07
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