Case-control study of six genes asymmetrically expressed in the two cerebral hemispheres: association of BAIAP2 with attention-deficit/hyperactivity disorder.

Détails

ID Serval
serval:BIB_E327AC7C7DC7
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Case-control study of six genes asymmetrically expressed in the two cerebral hemispheres: association of BAIAP2 with attention-deficit/hyperactivity disorder.
Périodique
Biological psychiatry
Auteur(s)
Ribasés M., Bosch R., Hervás A., Ramos-Quiroga J.A., Sánchez-Mora C., Bielsa A., Gastaminza X., Guijarro-Domingo S., Nogueira M., Gómez-Barros N., Kreiker S., Gross-Lesch S., Jacob C.P., Lesch K.P., Reif A., Johansson S., Plessen K.J., Knappskog P.M., Haavik J., Estivill X., Casas M., Bayés M., Cormand B.
ISSN
1873-2402 (Electronic)
ISSN-L
0006-3223
Statut éditorial
Publié
Date de publication
15/11/2009
Peer-reviewed
Oui
Volume
66
Numéro
10
Pages
926-934
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
Attention-deficit/hyperactivity disorder (ADHD) is a childhood-onset neuropsychiatric disease that persists into adulthood in at least 30% of patients. There is evidence suggesting that abnormal left-right brain asymmetries in ADHD patients may be involved in a variety of ADHD-related cognitive processes, including sustained attention, working memory, response inhibition and planning. Although mechanisms underlying cerebral lateralization are unknown, left-right cortical asymmetry has been associated with transcriptional asymmetry at embryonic stages and several genes differentially expressed between hemispheres have been identified.
We selected six functional candidate genes showing at least 1.9-fold differential expression between hemispheres (BAIAP2, DAPPER1, LMO4, NEUROD6, ATP2B3, and ID2) and performed a case-control association study in an initial Spanish sample of 587 ADHD patients (270 adults and 317 children) and 587 control subjects.
The single- and multiple-marker analysis provided evidence for a contribution of BAIAP2 to adulthood ADHD (p = .0026 and p = .0016, respectively). We thus tested BAIAP2 for replication in two independent adult samples from Germany (639 ADHD patients and 612 control subjects) and Norway (417 ADHD cases and 469 control subjects). While no significant results were observed in the Norwegian sample, we replicated the initial association between BAIAP2 and adulthood ADHD in the German population (p = .0062).
Our results support the participation of BAIAP2 in the continuity of ADHD across life span, at least in some of the populations analyzed, and suggest that genetic factors potentially influencing abnormal cerebral lateralization may be involved in this disorder.
Mots-clé
Adult, Age Factors, Attention Deficit Disorder with Hyperactivity/genetics, Case-Control Studies, Child, Confidence Intervals, Cross-Cultural Comparison, Female, Functional Laterality/genetics, Gene Frequency, Genetic Predisposition to Disease, Genome-Wide Association Study, Genotype, Germany, Humans, Male, Nerve Tissue Proteins/genetics, Norway, Odds Ratio, Polymorphism, Single Nucleotide, Spain
Pubmed
Web of science
Création de la notice
21/02/2019 9:43
Dernière modification de la notice
20/08/2019 16:06
Données d'usage