Prothrombinase-Induced Clotting Time to Measure Drug Concentrations of Rivaroxaban, Apixaban, and Edoxaban in Clinical Practice: A Cross-Sectional Study.

Détails

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Etat: Public
Version: Final published version
Licence: CC BY 4.0
ID Serval
serval:BIB_E303659E8D1E
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Prothrombinase-Induced Clotting Time to Measure Drug Concentrations of Rivaroxaban, Apixaban, and Edoxaban in Clinical Practice: A Cross-Sectional Study.
Périodique
Life
Auteur⸱e⸱s
Sathanantham V., Alberio L., Bovet C., Fontana P., Gerber B., Graf L., Mendez A., Sauter T.C., Schmidt A., Studt J.D., Wuillemin W.A., Nagler M.
ISSN
2075-1729 (Print)
ISSN-L
2075-1729
Statut éditorial
Publié
Date de publication
11/07/2022
Peer-reviewed
Oui
Volume
12
Numéro
7
Pages
1027
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: epublish
Résumé
Prothrombinase-induced clotting time (PiCT) is proposed as a rapid and inexpensive laboratory test to measure direct oral anticoagulant (DOAC) drug levels. In a prospective, multicenter cross-sectional study, including 851 patients, we aimed to study the accuracy of PiCT in determining rivaroxaban, apixaban, and edoxaban drug concentrations and assessed whether clinically relevant drug levels could be predicted correctly. Citrated plasma samples were collected, and the Pefakit <sup>®</sup> PiCT was utilized. Ultra-high performance liquid chromatography-tandem mass spectrometry (LC-MS/MS) was performed to measure drug concentrations. Cut-off levels were established using receiver-operating characteristics curves. We calculated sensitivities and specificities with respect to clinically relevant drug concentrations. Spearman's correlation coefficient between PiCT and drug concentrations was 0.85 in the case of rivaroxaban (95% CI 0.82, 0.88), 0.66 for apixaban (95% CI 0.60, 0.71), and 0.78 for edoxaban (95% CI 0.65, 0.86). The sensitivity to detect clinically relevant drug concentrations was 85.1% in the case of 30 µg L <sup>-1</sup> (95% CI 82.0, 87.7; specificity 77.9; 72.1, 82.7), 85.7% in the case of 50 µg L <sup>-1</sup> (82.4, 88.4; specificity 77.3; 72.5, 81.5), and 85.1% in the case of 100 µg L <sup>-1</sup> (80.9, 88.4; specificity 73.2%; 69.1, 76.9). In conclusion, the association of PiCT with DOAC concentrations was fair, and the majority of clinically relevant drug concentrations were correctly predicted.
Mots-clé
apixaban, cross-sectional studies, diagnostic accuracy, direct oral anticoagulants, edoxaban, laboratory monitoring, prothrombinase-induced clotting time, rivaroxaban, sensitivity and specificity
Pubmed
Web of science
Open Access
Oui
Création de la notice
02/08/2022 13:27
Dernière modification de la notice
23/01/2024 8:36
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