Effect of SR 49059, a V1a vasopressin receptor antagonist, in Raynaud's phenomenon.

Détails

ID Serval
serval:BIB_E30346AE93FE
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Effect of SR 49059, a V1a vasopressin receptor antagonist, in Raynaud's phenomenon.
Périodique
Rheumatology
Auteur(s)
Hayoz D., Bizzini G., Noël B., Depairon M., Burnier M., Fauveau C., Rouillon A., Brouard R., Brunner H.R.
ISSN
1462-0324 (Print)
ISSN-L
1462-0324
Statut éditorial
Publié
Date de publication
2000
Peer-reviewed
Oui
Volume
39
Numéro
10
Pages
1132-1138
Langue
anglais
Notes
Publication types: Clinical Trial ; Journal Article ; Randomized Controlled Trial
Publication Status: ppublish
Résumé
OBJECTIVE: To assess whether vasopressin V1a receptor blockade reduces the abnormal vasoactive response to cold in patients suffering from Raynaud's phenomenon (RP).
METHODS: SR 49059, an orally active, non-peptidic vasopressin V1a receptor antagonist, was given orally (300 mg once daily) to 20 patients with RP in a single-centre, double-blind, placebo-controlled, randomized cross-over study with two 7-day periods of treatment separated by 21 days of washout. Bilateral finger systolic blood pressure and skin temperature were assessed before and after immersion of the hand in cold water for 3 min (15 degrees C) during the screening phase and three times (before and 2 and 4 h after drug intake) on days 1 and 7 of each of the two treatment periods. Recovery of digital pressure and skin temperature was measured 0, 10, 20 and 32 min after the end of the cold immersion test.
RESULTS: SR 49059 significantly attenuated the cold-induced fall in systolic pressure by 14.5% (95% confidence interval 0-29; P = 0.045) on the most affected hand on day 7 compared with placebo. Temperature recovery after the end of the cold test showed a trend to enhancement 2 and 4 h after SR 49059 on day 7 (P = 0.060 and P = 0.062 respectively). The beneficial effects on finger pressure and temperature recovery were obtained without changes in supine blood pressure or in heart rate.
CONCLUSION: SR 49059 given orally once a day for 7 days to patients with RP showed favourable effects compared with placebo on finger systolic pressure and temperature recovery after cold immersion, without inducing side-effects.
Mots-clé
Adult, Aged, Blood Pressure/drug effects, Cold Temperature, Cross-Over Studies, Double-Blind Method, Female, Fingers/physiopathology, Hormone Antagonists/therapeutic use, Humans, Immersion, Indoles/therapeutic use, Male, Middle Aged, Pyrrolidines/therapeutic use, Raynaud Disease/drug therapy, Raynaud Disease/physiopathology, Receptors, Vasopressin/antagonists & inhibitors, Skin Temperature/drug effects
Pubmed
Web of science
Open Access
Oui
Création de la notice
29/01/2008 17:23
Dernière modification de la notice
20/08/2019 16:06
Données d'usage