Metabolomics: beyond biomarkers and towards mechanisms.
Détails
ID Serval
serval:BIB_E28159422E42
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Metabolomics: beyond biomarkers and towards mechanisms.
Périodique
Nature reviews. Molecular cell biology
ISSN
1471-0080 (Electronic)
ISSN-L
1471-0072
Statut éditorial
Publié
Date de publication
07/2016
Peer-reviewed
Oui
Volume
17
Numéro
7
Pages
451-459
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Publication Status: ppublish
Résumé
Metabolomics, which is the profiling of metabolites in biofluids, cells and tissues, is routinely applied as a tool for biomarker discovery. Owing to innovative developments in informatics and analytical technologies, and the integration of orthogonal biological approaches, it is now possible to expand metabolomic analyses to understand the systems-level effects of metabolites. Moreover, because of the inherent sensitivity of metabolomics, subtle alterations in biological pathways can be detected to provide insight into the mechanisms that underlie various physiological conditions and aberrant processes, including diseases.
Mots-clé
Animals, Biomarkers/metabolism, Humans, Metabolic Networks and Pathways, Metabolome, Metabolomics, Systems Biology
Pubmed
Création de la notice
17/03/2016 18:26
Dernière modification de la notice
20/08/2019 17:06