Detection of perforin and granzyme A mRNA in infiltrating cells during infection of mice with lymphocytic choriomeningitis virus.

Détails

ID Serval
serval:BIB_E24B1B9F9BA1
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Detection of perforin and granzyme A mRNA in infiltrating cells during infection of mice with lymphocytic choriomeningitis virus.
Périodique
European journal of immunology
Auteur(s)
Müller C., Kägi D., Aebischer T., Odermatt B., Held W., Podack E.R., Zinkernagel R.M., Hengartner H.
ISSN
0014-2980
Statut éditorial
Publié
Date de publication
1989
Peer-reviewed
Oui
Volume
19
Numéro
7
Pages
1253-1259
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S.
Publication Status: ppublish
Résumé
The analysis of gene expression in cytotoxic T cells by in situ hybridization of serial liver and brain sections from mice infected with lymphocytic choriomeningitis virus (LCMV) and immunostaining with T cell marker- and virus-specific antibodies revealed a close histological association of infiltrating lymphocytes expressing the perforin and granzyme A genes with virally infected cells. Maximal frequency of perforin and granzyme A mRNA-containing cells on liver sections preceded by about 2 days maximal LCMV-specific cytotoxicity of the lymphoid liver infiltrating cells. These results are most consistent with an involvement of perforin and granzyme A in cell-mediated cytotoxicity in vivo.
Mots-clé
Animals, Brain/microbiology, Brain/physiopathology, Gene Expression Regulation, Granzymes, Hepatitis, Viral, Animal/genetics, Immunoenzyme Techniques, Liver/microbiology, Liver/pathology, Lymphocytic Choriomeningitis/microbiology, Lymphocytic Choriomeningitis/pathology, Membrane Glycoproteins, Membrane Proteins/genetics, Mice, Nucleic Acid Hybridization, Perforin, Pore Forming Cytotoxic Proteins, RNA Probes, RNA, Messenger/genetics, Serine Endopeptidases/genetics, T-Lymphocytes, Cytotoxic/physiology, Time Factors
Pubmed
Web of science
Création de la notice
17/01/2008 15:24
Dernière modification de la notice
20/08/2019 16:06
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