Understanding the multifaceted role of inflammatory mediators in ischemic stroke.

Détails

ID Serval
serval:BIB_E22F7DC45ECC
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Understanding the multifaceted role of inflammatory mediators in ischemic stroke.
Périodique
Current Medicinal Chemistry
Auteur(s)
Amantea D., Tassorelli C., Petrelli F., Certo M., Bezzi P., Micieli G., Corasaniti M.T., Bagetta G.
ISSN
1875-533X (Electronic)
ISSN-L
0929-8673
Statut éditorial
Publié
Date de publication
2014
Peer-reviewed
Oui
Volume
21
Numéro
18
Pages
2098-2117
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't Publication Status: ppublish
Résumé
The evolution of ischemic brain damage is strongly affected by an inflammatory reaction that involves soluble mediators, such as cytokines and chemokines, and specialized cells activated locally or recruited from the periphery. The immune system affects all phases of the ischemic cascade, from the acute intravascular reaction due to blood flow disruption, to the development of brain tissue damage, repair and regeneration. Increased endothelial expression of adhesion molecules and blood-brain barrier breakdown promotes extravasation and brain recruitment of blood-borne cells, including macrophages, neutrophils, dendritic cells and T lymphocytes, as demonstrated both in animal models and in human stroke. Nevertheless, most anti-inflammatory approaches showing promising results in experimental stroke models failed in the clinical setting. The lack of translation may reside in the redundancy of most inflammatory mediators, exerting both detrimental and beneficial functions. Thus, this review is aimed at providing a better understanding of the dualistic role played by each component of the inflammatory/immune response in relation to the spatio-temporal evolution of ischemic stroke injury.
Pubmed
Web of science
Création de la notice
08/09/2014 13:24
Dernière modification de la notice
20/08/2019 17:06
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