Whole genome linkage scan of recurrent depressive disorder from the depression network study
Détails
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Etat: Public
Version: Final published version
Licence: Non spécifiée
It was possible to publish this article open access thanks to a Swiss National Licence with the publisher.
Etat: Public
Version: Final published version
Licence: Non spécifiée
It was possible to publish this article open access thanks to a Swiss National Licence with the publisher.
ID Serval
serval:BIB_E16FCEB3A156
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Whole genome linkage scan of recurrent depressive disorder from the depression network study
Périodique
Human Molecular Genetics
ISSN
0964-6906
Statut éditorial
Publié
Date de publication
2005
Peer-reviewed
Oui
Volume
14
Numéro
22
Pages
3337-3345
Langue
anglais
Notes
SAPHIRID:62840
Résumé
Genome-wide linkage analysis was carried out in a sample of 497 sib pairs concordant for recurrent major depressive disorder (MDD). There was suggestive evidence for linkage on chromosome 1p36 where the LOD score for female-female pairs exceeded 3 (but reduced to 2.73 when corrected for multiple testing). The region includes a gene, MTHFR, that in previous studies has been associated with depressive symptoms. Two other regions, on chromosomes 12q23.3-q24.11 and 13q31.1-q31.3, showed evidence for linkage with a nominal P < 0.01. The 12q peak overlaps with a region previously implicated by linkage studies of unipolar and bipolar disorders and contains a gene, DAO, that has been associated with both bipolar disorder and schizophrenia. The 13q peak lies within a region previously linked strongly to panic disorder. A fourth modest peak with an LOD of greater than 1 on chromosome 15q lies within a region that showed genome-wide significant evidence of a recurrent depression locus in a previous sib-pair study. Both the 12q and the 15q findings remained significant at genome-wide level when the data from the present study and the previous reports were combined.
Pubmed
Web of science
Open Access
Oui
Création de la notice
13/03/2008 9:39
Dernière modification de la notice
14/02/2022 8:57