In vivo and in vitro development of alpha-MSH and ACTH in the embryonic and postnatal rat brain.

Détails

ID Serval
serval:BIB_E130235E0ABF
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
In vivo and in vitro development of alpha-MSH and ACTH in the embryonic and postnatal rat brain.
Périodique
Developmental Brain Research
Auteur(s)
Monnet-Tschudi F., Eberle A.N., Honegger P.
ISSN
0165-3806
Statut éditorial
Publié
Date de publication
04/1986
Volume
391
Numéro
1
Pages
125-132
Langue
anglais
Résumé
The appearance of immunoreactive alpha-melanotropin (alpha-MSH) and adrenocorticotropin (ACTH) during development was studied in 3 areas of the rat brain--cerebral hemispheres, midbrain and hindbrain--from embryonic day (ED) 13-14 until day 21 postnatally. The alpha-MSH content in vivo was always highest in the midbrain; a peak content at birth was followed by a transient decline and a later, higher plateau from postnatal day 7 onwards. The alpha-MSH content in the cerebral hemispheres rose progressively after birth reaching a peak at day 21. Values in the hindbrain rose at day 3 and changed relatively sue taken at ED 15-16 showed a gradual increase in alpha-MSH content over the 20 days. The alpha-MSH content of hindbrain cultures remained at constant low levels, while no alpha-MSH was detectable in cerebral hemisphere cultures. ACTH appeared in vivo earlier than alpha-MSH and was detectable in embryonic brains at ED 13-14. A transient rise was seen at ED 17-18 and major peaks at birth, day 2 and day 3, in the midbrain, hemispheres and hindbrain, respectively. In vitro, the ACTH content increased in all brain regions during the first 5 days in culture and showed no further change thereafter. Comparisons of the in vivo and in vitro development of alpha-MSH and ACTH demonstrate that (i) these two peptide systems are independent in respect to their localization and time of appearance; (ii) they undergo maturation both in vivo and in vitro; (iii) epigenetic factors, such as interactions with other neurotransmitter systems may modulate the developmental pattern of these two peptides.
Mots-clé
Adrenocorticotropic Hormone/analysis, Age Factors, Animals, Brain/embryology, Brain/growth & development, Brain Chemistry, Cells, Cultured, Melanocyte-Stimulating Hormones/analysis, Radioimmunoassay, Rats, Rats, Inbred Strains
Pubmed
Web of science
Création de la notice
24/01/2008 14:11
Dernière modification de la notice
20/08/2019 17:05
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