Combination of PET and Magnetoencephalography in the Presurgical Assessment of MRI-Negative Epilepsy

Détails

ID Serval
serval:BIB_E0C76500D8C5
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Combination of PET and Magnetoencephalography in the Presurgical Assessment of MRI-Negative Epilepsy
Périodique
Front Neurol
Auteur⸱e⸱s
Rheims S., Jung J., Ryvlin P.
ISSN
1664-2295 (Print)
ISSN-L
1664-2295
Statut éditorial
Publié
Date de publication
2013
Volume
4
Pages
188
Langue
anglais
Notes
Rheims, Sylvain
Jung, Julien
Ryvlin, Philippe
eng
Review
Switzerland
Front Neurol. 2013 Nov 21;4:188. doi: 10.3389/fneur.2013.00188.
Résumé
Despite major advances in neuroimaging, no lesion is visualized on MRI in up to a quarter of patients with drug-resistant focal epilepsy presenting for presurgical evaluation. These patients demonstrate poorer surgical outcomes than those with lesion seen on MRI. Accurate localization of the seizure onset zone (SOZ) is more difficult in MRI-negative patients and often requires invasive EEG recordings. Positron emission tomography (PET) and magnetoencephalography (MEG) have been proposed as clinically relevant tools to localize the SOZ prior to intracranial EEG recordings. However, there is no consensus regarding the optimal gold standard that should be used for assessing the performance of these presurgical investigations. Here, we review the current knowledge concerning the usefulness of PET and MEG for presurgical assessment of MRI-negative epilepsy. Beyond the individual diagnostic performance of MEG and of different PET tracers, including [(18)F]-fluorodeoxyglucose, [(11)C]flumazenil, and markers of 5-HT1A receptors, recent data suggest that the combination of PET and MEG might provide greater sensitivity and specificity than that of each of the two individual tests in patients with normal MRI.
Mots-clé
Pet, epilepsy surgery, magnetoencephalography, partial epilepsy
Pubmed
Open Access
Oui
Création de la notice
29/11/2018 12:37
Dernière modification de la notice
20/08/2019 16:05
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