Embryonic and induced pluripotent stem cell differentiation as a tool in neurobiology.

Détails

ID Serval
serval:BIB_E044792BFB8F
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Embryonic and induced pluripotent stem cell differentiation as a tool in neurobiology.
Périodique
Biotechnology journal
Auteur⸱e⸱s
Nikoletopoulou V., Tavernarakis N.
ISSN
1860-7314 (Electronic)
ISSN-L
1860-6768
Statut éditorial
Publié
Date de publication
09/2012
Peer-reviewed
Oui
Volume
7
Numéro
9
Pages
1156-1168
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Publication Status: ppublish
Résumé
Cell lines with the ability to differentiate into all types of somatic and germ cells represent a pluripotent developmental stage that transiently exists in vivo in the epiblast cells of the pre-implantation embryo. Given the lack of access to human neurons, together with the limited numbers and heterogeneity of neurons obtainable from rodent primary cultures, the directed differentiation of pluripotent cell lines into defined cells of the neural lineage has provided a novel versatile tool in neurobiology. Offering a potentially unlimited source of material, directed differentiation of pluripotent cell lines has been particularly well combined with high-throughput transcriptomic and epigenetic analyses. Here, we first overview the potential of different pluripotent lines to give rise to different types of neurons. Then, we discuss the emerging use of neuronal differentiation systems as a tool for unravelling mechanisms that regulate neuronal development and specification, modelling complex neurological diseases and understanding neuronal dysfunction. Beyond providing original insights in many aspects of neuronal biology, these tools have greatly facilitated the development of novel therapeutic interventions for neurological disorders.
Mots-clé
Animals, Cell Differentiation/physiology, Embryonic Stem Cells/cytology, Humans, Mice, Neurobiology/methods, Pluripotent Stem Cells/cytology, Stem Cell Research
Pubmed
Web of science
Création de la notice
04/06/2024 10:47
Dernière modification de la notice
05/06/2024 9:07
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