Electronic monitoring of long-term use of the nicotine nasal spray and predictors of success in a smoking cessation program

Détails

ID Serval
serval:BIB_E01CCF36E2A3
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Electronic monitoring of long-term use of the nicotine nasal spray and predictors of success in a smoking cessation program
Périodique
Nicotine and Tobacco Research
Auteur⸱e⸱s
Schneider  M. P., van Melle  G., Uldry  C., Huynh-Ba  M., Fallab Stubi  C. L., Iorillo  D., Burnier  M., Zellweger  J. P.
ISSN
1462-2203 (Print)
Statut éditorial
Publié
Date de publication
10/2003
Volume
5
Numéro
5
Pages
719-27
Notes
Clinical Trial Journal Article Research Support, Non-U.S. Gov't --- Old month value: Oct
Résumé
This study evaluated the efficacy of prolonged administration (18 months) of a nicotine nasal spray in smoking cessation and attempted to characterize the pattern of use of the nasal spray with a specially developed electronic monitor in an effort to assess the factors associated with cessation success or failure. Study participants were 92 patients in a smoking cessation unit of a medical outpatient clinic in Switzerland. Participants were daily smokers who had smoked for more than 5 years and were highly motivated to quit. The main outcome measure was the number of abstainers at 12 and 24 months. Their use of the spray was monitored using a microchip (MDILog) that recorded the date and time of every actuation. Success rates were 17.4% at 12 months and 9.8% at 24 months. During the first month of study, median use was 12 puffs/day in abstainers and 6 puffs/day in failures (p=.049). Abstainers used the spray less in the morning compared with failures (26.6% vs. 32.8% of the total median daily dose; p=.028). By contrast, abstainers used the spray more in the evening/night compared with failures (35.3% vs. 26.7% of the total median daily dose; p=.007). Abstinence during the first two weeks was associated significantly with cessation success at 6 months (OR=17.10) and 24 months (OR=11.09). Although the pattern of use of the nasal spray differed between successful quitters and failures (used in higher doses by the successful quitters), mean daily consumption during the first month was not predictive of success. Mean daily consumption of the nicotine nasal spray remained lower than expected in most participants, particularly in failures.
Mots-clé
Administration, Inhalation Adult Aged Automation Drug Administration Schedule Electronics Female Ganglionic Stimulants/*administration & dosage/pharmacology Humans Male Middle Aged Monitoring, Physiologic/methods Motivation Nicotine/*administration & dosage/pharmacology *Patient Compliance Predictive Value of Tests Prospective Studies Smoking Cessation/*methods Tobacco Use Disorder/*drug therapy Treatment Outcome
Pubmed
Web of science
Création de la notice
25/01/2008 12:55
Dernière modification de la notice
20/08/2019 16:04
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