Increased fat oxidation in prepubertal obese children: a metabolic defense against further weight gain?

Détails

ID Serval
serval:BIB_DFFAAC6EB60F
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Increased fat oxidation in prepubertal obese children: a metabolic defense against further weight gain?
Périodique
Journal of Pediatrics
Auteur⸱e⸱s
Maffeis C., Pinelli L., Schutz Y.
ISSN
0022-3476 (Print)
ISSN-L
0022-3476
Statut éditorial
Publié
Date de publication
01/1995
Volume
126
Numéro
1
Pages
15-20
Langue
anglais
Notes
Publication types: Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
The purpose of this study was to measure postabsorptive fat oxidation at rest and to assess the association between fat mass and fat oxidation rate in prepubertal children, who were assigned to two groups: 35 obese children (weight, 44.5 +/- 9.7 kg; fat mass; 31.7 +/- 5.4%) and 37 nonobese children (weight, 30.8 +/- 6.8 kg; fat mass, 17.5 +/- 6.7%). Postabsorptive fat oxidation expressed in absolute value was significantly higher in obese than in nonobese children (31.4 +/- 9.7 mg/min vs 21.9 +/- 10.2 mg/min; p < 0.001) but not when adjusted for fat-free mass by analysis of covariance with fat-free mass as the covariate (28.2 +/- 10.6 mg/min vs 24.9 +/- 10.5 mg/min). In obese children and in the total group, fat mass and fat oxidation were significantly correlated (r = 0.65; p < 0.001). The slope of the relationship indicated that for each 10 kg additional fat mass, resting fat oxidation increased by 18 gm/day. We conclude that obese prepubertal children have a higher postabsorptive rate of fat oxidation than nonobese children. This metabolic process may favor the achievement of a new equilibrium in fat balance, opposing further adipose tissue gain.
Mots-clé
Adipose Tissue/metabolism, Body Mass Index, Body Weight, Child, Female, Humans, Male, Metabolic Clearance Rate, Obesity/metabolism, Obesity/prevention & control, Oxidation-Reduction, Oxygen/metabolism, Puberty/metabolism, Weight Gain
Pubmed
Web of science
Création de la notice
21/01/2008 13:08
Dernière modification de la notice
20/08/2019 16:04
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