Vers un traitement des démences [Toward a treatment for dementia].

Détails

ID Serval
serval:BIB_DFF97FBD4730
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Vers un traitement des démences [Toward a treatment for dementia].
Périodique
Praxis
Auteur(s)
Ghika J.
ISSN
1661-8157 (Print)
ISSN-L
1661-8157
Statut éditorial
Publié
Date de publication
1995
Volume
84
Numéro
38
Pages
1050-1053
Langue
français
Notes
Publication types: English Abstract ; Journal Article ; Review Publication Status: ppublish
Résumé
The clinical manifestations of so-called 'untreatable dementias' result from neuronal dysfunction causing premature neuronal death. As long as the neurosciences won't have an explanation for the increased vulnerability and cause of death of neurons in neurodegenerative disorders, no preventive or curative treatment can be expected. So far, the treatment of dementia focuses essentially on the consequences of neuronal dysfunction or cell loss by either a palliative approach addressing psychosis, behavior or anxiety and depression, or by substitution of deficient neurotransmitters with quasi no success. Only tacrine, a cholinesterase inhibitor, now available in Switzerland, has a marginal effect in early cases, but every other substitutive approach has failed so far. Muscarinic agonists as well as antiamyloid substances will be tested soon in clinical trials. Growth factors (especially NGF) raise big hopes for the near future, but they are still under preclinical evaluation.
Mots-clé
Aged, Alzheimer Disease/therapy, Cholinesterase Inhibitors/therapeutic use, Dementia/therapy, Humans, Middle Aged, Nerve Growth Factors/therapeutic use, Palliative Care, Tacrine/therapeutic use
Pubmed
Création de la notice
25/01/2008 12:46
Dernière modification de la notice
20/08/2019 17:04
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