Genome-wide association study of circulating interleukin 6 levels identifies novel loci.

Détails

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Etat: Public
Version: Final published version
Licence: CC BY 4.0
ID Serval
serval:BIB_DFC20881CC51
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Genome-wide association study of circulating interleukin 6 levels identifies novel loci.
Périodique
Human molecular genetics
Auteur⸱e⸱s
Ahluwalia T.S., Prins B.P., Abdollahi M., Armstrong N.J., Aslibekyan S., Bain L., Jefferis B., Baumert J., Beekman M., Ben-Shlomo Y., Bis J.C., Mitchell B.D., de Geus E., Delgado G.E., Marek D., Eriksson J., Kajantie E., Kanoni S., Kemp J.P., Lu C., Marioni R.E., McLachlan S., Milaneschi Y., Nolte I.M., Petrelis A.M., Porcu E., Sabater-Lleal M., Naderi E., Seppälä I., Shah T., Singhal G., Standl M., Teumer A., Thalamuthu A., Thiering E., Trompet S., Ballantyne C.M., Benjamin E.J., Casas J.P., Toben C., Dedoussis G., Deelen J., Durda P., Engmann J., Feitosa M.F., Grallert H., Hammarstedt A., Harris S.E., Homuth G., Hottenga J.J., Jalkanen S., Jamshidi Y., Jawahar M.C., Jess T., Kivimaki M., Kleber M.E., Lahti J., Liu Y., Marques-Vidal P., Mellström D., Mooijaart S.P., Müller-Nurasyid M., Penninx B., Revez J.A., Rossing P., Räikkönen K., Sattar N., Scharnagl H., Sennblad B., Silveira A., Pourcain B.S., Timpson N.J., Trollor J., van Dongen J., Van Heemst D., Visvikis-Siest S., Vollenweider P., Völker U., Waldenberger M., Willemsen G., Zabaneh D., Morris R.W., Arnett D.K., Baune B.T., Boomsma D.I., Chang Y.C., Deary I.J., Deloukas P., Eriksson J.G., Evans D.M., Ferreira M.A., Gaunt T., Gudnason V., Hamsten A., Heinrich J., Hingorani A., Humphries S.E., Jukema J.W., Koenig W., Kumari M., Kutalik Z., Lawlor D.A., Lehtimäki T., März W., Mather K.A., Naitza S., Nauck M., Ohlsson C., Price J.F., Raitakari O., Rice K., Sachdev P.S., Slagboom E., Sørensen TIA, Spector T., Stacey D., Stathopoulou M.G., Tanaka T., Wannamethee S.G., Whincup P., Rotter J.I., Dehghan A., Boerwinkle E., Psaty B.M., Snieder H., Alizadeh B.Z.
Collaborateur⸱rice⸱s
CHARGE Inflammation Working Group
ISSN
1460-2083 (Electronic)
ISSN-L
0964-6906
Statut éditorial
Publié
Date de publication
27/04/2021
Peer-reviewed
Oui
Volume
30
Numéro
5
Pages
393-409
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
Interleukin 6 (IL-6) is a multifunctional cytokine with both pro- and anti-inflammatory properties with a heritability estimate of up to 61%. The circulating levels of IL-6 in blood have been associated with an increased risk of complex disease pathogenesis. We conducted a two-staged, discovery and replication meta genome-wide association study (GWAS) of circulating serum IL-6 levels comprising up to 67 428 (ndiscovery = 52 654 and nreplication = 14 774) individuals of European ancestry. The inverse variance fixed effects based discovery meta-analysis, followed by replication led to the identification of two independent loci, IL1F10/IL1RN rs6734238 on chromosome (Chr) 2q14, (Pcombined = 1.8 × 10-11), HLA-DRB1/DRB5 rs660895 on Chr6p21 (Pcombined = 1.5 × 10-10) in the combined meta-analyses of all samples. We also replicated the IL6R rs4537545 locus on Chr1q21 (Pcombined = 1.2 × 10-122). Our study identifies novel loci for circulating IL-6 levels uncovering new immunological and inflammatory pathways that may influence IL-6 pathobiology.
Pubmed
Web of science
Open Access
Oui
Création de la notice
08/02/2021 14:08
Dernière modification de la notice
12/01/2022 7:14
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