Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival.

Détails

ID Serval
serval:BIB_DF9221D8DB57
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival.
Périodique
Nature Medicine
Auteur(s)
Curiel T.J., Coukos G., Zou L., Alvarez X., Cheng P., Mottram P., Evdemon-Hogan M., Conejo-Garcia J.R., Zhang L., Burow M., Zhu Y., Wei S., Kryczek I., Daniel B., Gordon A., Myers L., Lackner A., Disis M.L., Knutson K.L., Chen L., Zou W.
ISSN
1078-8956 (Print)
ISSN-L
1078-8956
Statut éditorial
Publié
Date de publication
2004
Volume
10
Numéro
9
Pages
942-949
Langue
anglais
Notes
Publication types: Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, U.S. Gov't, P.H.S.Publication Status: ppublish
Résumé
Regulatory T (T(reg)) cells mediate homeostatic peripheral tolerance by suppressing autoreactive T cells. Failure of host antitumor immunity may be caused by exaggerated suppression of tumor-associated antigen-reactive lymphocytes mediated by T(reg) cells; however, definitive evidence that T(reg) cells have an immunopathological role in human cancer is lacking. Here we show, in detailed studies of CD4(+)CD25(+)FOXP3(+) T(reg) cells in 104 individuals affected with ovarian carcinoma, that human tumor T(reg) cells suppress tumor-specific T cell immunity and contribute to growth of human tumors in vivo. We also show that tumor T(reg) cells are associated with a high death hazard and reduced survival. Human T(reg) cells preferentially move to and accumulate in tumors and ascites, but rarely enter draining lymph nodes in later cancer stages. Tumor cells and microenvironmental macrophages produce the chemokine CCL22, which mediates trafficking of T(reg) cells to the tumor. This specific recruitment of T(reg) cells represents a mechanism by which tumors may foster immune privilege. Thus, blocking T(reg) cell migration or function may help to defeat human cancer.
Mots-clé
Animals, Ascites/immunology, CD4-Positive T-Lymphocytes, Cell Movement/immunology, Chemokine CCL22, Chemokines, CC/immunology, Chemokines, CC/metabolism, DNA-Binding Proteins, Dendritic Cells/immunology, Female, Forkhead Transcription Factors, Humans, Immunity, Cellular/immunology, Immunophenotyping, Lymphocyte Activation/immunology, Mice, Microscopy, Confocal/methods, Ovarian Neoplasms/immunology, Receptors, Interleukin-2, T-Lymphocytes/immunology
Pubmed
Web of science
Création de la notice
14/10/2014 12:43
Dernière modification de la notice
20/08/2019 17:03
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