The effect of sex and age on antithrombin biosynthesis in the rat

Détails

ID Serval
serval:BIB_DECFB7174F80
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
The effect of sex and age on antithrombin biosynthesis in the rat
Périodique
Thrombosis Research
Auteur(s)
Kourteva  Y., Schapira  M., Patston  P. A.
ISSN
0049-3848 (Print)
Statut éditorial
Publié
Date de publication
06/1995
Volume
78
Numéro
6
Pages
521-9
Notes
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S. --- Old month value: Jun 15
Résumé
Antithrombin is the primary inhibitor of Factor Xa and thrombin. Numerous reports have indicated that age and sex can influence antithrombin levels, but details of the regulation of antithrombin biosynthesis are not known. Thus, a characterization of antithrombin mRNA in eight tissues of young and old male and female rats was carried out. Liver produced the most mRNA, and hence contributes the majority of the plasma antithrombin, followed by the kidneys, with no age or sex related differences in mRNA levels being observed. Elevated amounts of mRNA were detected in aortas of old male rats compared to young ones. No antithrombin mRNA was detected in brain, lung, heart or skeletal muscle, and spleen showed low but variable levels. Plasma antithrombin protein was elevated in old female rats compared to young female or old male rats. These results show that the rat provides a potentially useful system to study the in vivo regulation of antithrombin biosynthesis.
Mots-clé
Age Factors Animals Antithrombin III/*biosynthesis/genetics Aorta/chemistry Base Sequence Blotting, Northern Female Liver/chemistry Male Molecular Sequence Data Organ Specificity RNA, Messenger/analysis Rats Rats, Sprague-Dawley Sex Factors
Pubmed
Web of science
Création de la notice
25/01/2008 16:28
Dernière modification de la notice
20/08/2019 17:03
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