A new technique with high reproducibility to estimate renal oxygenation using BOLD-MRI in chronic kidney disease.

Détails

ID Serval
serval:BIB_DEC39B5AFEAD
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
A new technique with high reproducibility to estimate renal oxygenation using BOLD-MRI in chronic kidney disease.
Périodique
Magnetic Resonance Imaging
Auteur(s)
Piskunowicz M., Hofmann L., Zuercher E., Bassi I., Milani B., Stuber M., Narkiewicz K., Vogt B., Burnier M., Pruijm M.
ISSN
1873-5894 (Electronic)
ISSN-L
0730-725X
Statut éditorial
Publié
Date de publication
12/2015
Peer-reviewed
Oui
Volume
33
Numéro
3
Pages
253-261
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
OBJECTIVES: To assess inter-observer variability of renal blood oxygenation level-dependent MRI (BOLD-MRI) using a new method of analysis, called the concentric objects (CO) technique, in comparison with the classical ROI (region of interest)-based technique.
METHODS: MR imaging (3T) was performed before and after furosemide in 10 chronic kidney disease (CKD) patients (mean eGFR 43±24ml/min/1.73m(2)) and 10 healthy volunteers (eGFR 101±28ml/min1.73m(2)), and R2* maps were determined on four coronal slices. In the CO-technique, R2* values were based on a semi-automatic procedure that divided each kidney in six equal layers, whereas in the ROI-technique, all circles (ROIs) were placed manually in the cortex and medulla. The mean R2*values as assessed by two independent investigators were compared.
RESULTS: With the CO-technique, inter-observer variability was 0.7%-1.9% across all layers in non-CKD, versus 1.6%-3.8% in CKD. With the ROI-technique, median variability for cortical and medullary R2* values was 3.6 and 6.8% in non-CKD, versus 4.7 and 12.5% in CKD; similar results were observed after furosemide.
CONCLUSION: The CO-technique offers a new, investigator-independent, highly reproducible alternative to the ROI-based technique to estimate renal tissue oxygenation in CKD.
Pubmed
Web of science
Création de la notice
15/01/2015 12:56
Dernière modification de la notice
20/08/2019 17:03
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