Reduced rapid eye movement sleep in late middle-aged and older apolipoprotein E ɛ4 allele carriers.

Détails

ID Serval
serval:BIB_DEA77A0A30B0
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Reduced rapid eye movement sleep in late middle-aged and older apolipoprotein E ɛ4 allele carriers.
Périodique
Sleep
Auteur⸱e⸱s
André C., Martineau-Dussault M.È., Baril A.A., Marchi N.A., Daneault V., Lorrain D., Hudon C., Bastien C.H., Petit D., Thompson C., Poirier J., Montplaisir J., Gosselin N., Carrier J.
ISSN
1550-9109 (Electronic)
ISSN-L
0161-8105
Statut éditorial
Publié
Date de publication
11/07/2024
Peer-reviewed
Oui
Volume
47
Numéro
7
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
Apolipoprotein E ɛ4 (APOE4) is the strongest genetic risk factor for Alzheimer's disease (AD). In addition, APOE4 carriers may exhibit sleep disturbances, but conflicting results have been reported, such that there is no clear consensus regarding which aspects of sleep are impacted. Our objective was to compare objective sleep architecture between APOE4 carriers and non-carriers, and to investigate the modulating impact of age, sex, cognitive status, and obstructive sleep apnea (OSA).
A total of 198 dementia-free participants aged >55 years old (mean age: 68.7 ± 8.08 years old, 40.91% women, 41 APOE4 carriers) were recruited in this cross-sectional study. They underwent polysomnography, APOE4 genotyping, and a neuropsychological evaluation. ANCOVAs assessed the effect of APOE4 status on sleep architecture, controlling for age, sex, cognitive status, and the apnea-hypopnea index. Interaction terms were added between APOE4 status and covariates.
Rapid eye movement (REM) sleep percentage (F = 9.95, p = .002, ηp2 = 0.049) and duration (F = 9.23, p = .003, ηp2 = 0.047) were lower in APOE4 carriers. The results were replicated in a subsample of 112 participants without moderate-to-severe OSA. There were no significant interactions between APOE4 status and age, sex, cognitive status, and OSA in the whole sample.
Our results show that APOE4 carriers exhibit lower REM sleep duration, including in cognitively unimpaired individuals, possibly resulting from early neurodegenerative processes in regions involved in REM sleep generation and maintenance.
Mots-clé
Humans, Female, Apolipoprotein E4/genetics, Male, Cross-Sectional Studies, Polysomnography, Sleep, REM/physiology, Sleep, REM/genetics, Aged, Middle Aged, Heterozygote, Sleep Apnea, Obstructive/genetics, Sleep Apnea, Obstructive/physiopathology, Neuropsychological Tests/statistics & numerical data, Alleles, Genotype, Cognition/physiology, APOE4, Alzheimer’s disease, REM sleep, aging, dementia, mild cognitive impairment, polysomnography, sleep
Pubmed
Web of science
Open Access
Oui
Création de la notice
19/04/2024 9:38
Dernière modification de la notice
16/07/2024 7:09
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